科瑞迈德 环状mRNA cmRNA1210 2022年9月15日蚌埠医学院第二医院启动临床. 参考资料 Emily M Cheng et al, Interleukin-12 as an in situ cancer vaccine component: a review, Cancer Immunol Immunother . 2022 Sep;71(9):2057-2065. Benedito A. Carneiro, Dmitriy Zamarin...
Although treatment with vaccine and IL-12 increased levels of IFN-γ mRNA, IL-12-mediated enhancement of antibody responses still occurred in IFN-γ/ mice. The results demonstrate the effectiveness of IL-12 as an adjuvant for polysaccharide conjugate vaccines, especially the pneumococcal conjugate ...
et al. Intratumoral delivery of IL-12 and IL-27 mRNA using lipid nanoparticles for cancer immunotherapy. J. Control. Release 345, 306–313 (2022). CAS PubMed PubMed Central Google Scholar Liu, M. A. A comparison of plasmid DNA and mRNA as vaccine technologies. Vaccines 7, 37 (2019)...
3.Vaccine design using our proprietary bioinformatics algorithm for up to 34 patient-specific neoantigens; 4.Manufacture of the designedmRNA; and 5.Administration of the mRNA to the same patient that provided the tumor sample. Specifically, for each patient, the tumor sample and peripheral blood s...
IL-12抑制剂[+1] 在研机构 Biocon Ltd.[+3] 原研机构 Biocon Ltd. 在研适应症 银屑病关节炎[+7] 非在研适应症- 最高研发阶段批准上市 首次获批国家/地区 美国 首次获批日期2024-11-29 Ustekinumab Biosimilar (Qyuns Therapeutics) 乌司奴单抗生物类似药 (荃信生物) ...
We previously reported that transient engineering of tumor-specific CD8 T cells with IL-12 mRNA enhanced their systemic therapeutic efficacy when delivered intratumorally. Here, we mix T cells engineered with mRNAs to express either single-chain IL-12 (scIL-12) or an IL-18 decoy-resistant ...
Combination therapy with oncolytic virus and T cells or mRNA vaccine amplifies antitumor effects Article Open access 03 May 2024 Oncolytic virus promotes tumor-reactive infiltrating lymphocytes for adoptive cell therapy Article 07 July 2020 Introduction Over the past decade, tumor immunology has adv...
Immorna has a growing intellectual property portfolio and a diverse RNA development pipeline spanning cancer immunotherapy, infectious diseases, rare genetic diseases, and medical cosmetology, and quickly advancing its oncology drug and infectious disease vaccine candidates into clinical stages....
Analysis of pulmonary cytokine mRNA responses demonstrated that control challenged mice elicited a dominant Th2-type response, 3X/saline-vaccinated produced a mixed Th1/Th2-type cytokine response, while 3X/IL-12-immunized animals displayed a dominant Th1-type response. The IL-12-treated group also...
IL一12 能使 小 鼠脾 细胞的 IL一10mRNA 表达量 增加46 倍 。由于 IL一1O 可抑 制 IL一12 的某 些功 能 , 因此II 一12 诱导 II 一1O 生成 可能 是体 内的 一种 反馈 调节。有 研究 报道 ,II 一l 2 可诱 导人 P HA 激活 的胚 ...