2021年9月28日,在Nature杂志上发表了一篇名为“B cell-derived GABA elicits IL-10+ macrophages to limit anti-tumour immunity”的文章,描述B细胞衍生的GABA如何引发IL-10+巨噬细胞以限制抗肿瘤免疫。在这里,该团推通过从B细胞合成并分泌GABA,B细胞通过GABA限制细胞毒性T细胞,GABA引发抗炎TAM和GABA调节巨噬细胞...
近日,来自广州医科大学附属肿瘤医院、研究所的研究者们在Cell Death and Disease杂志上发表了题为“B cell-derived IL-10 promotes the resolution of lipopolysaccharide-induced acute lung injury”的文章,该研究强调,B细胞来源的IL-10对于内毒素诱导的ALI的解决至关重要,并可能成为潜在的治疗靶点。 炎症消退是急性...
B cellsB‐cell malignanciesDNA methylationepigeneticsInterleukin 10Among the family of regulatory B cells, the subset able to produce interleukin (IL) is the most studied, yet its biology is still a matter of investigation. The DNA methylation profiling of the il gene locus revealed a novel ...
Recently, the ability of B cells to negatively regulate cellular immune responses and inflammation has been described and the concept of regulatory B cells has emerged. A variety of cytokines produced by regulatory B cell subsets have been reported, with IL-10 being the most studied. In this ...
Moreover, each IL-10-producing B cell in DTC patients produced more IL-10 than the counterparts in healthy controls. This IL-10+ subset was enriched in the CD27+ fraction. Under an in vitro setting, CD27+ B cells inhibited IFN-纬 expression from CD4+ T cells and IFN-纬, perforin, ...
The modulation of IL-10 producing B cells on Th response after 1,3-β-glucan treatment was cell contact independent. What's more, the modulation pattern of IL-10 producing B cells might be impaired without Treg response. IL-10-producing B cells regulated 1,3-β-glucan induced Th responses...
近日来自日本横滨研究所综合医学中心粘膜免疫实验室确定了代谢物和神经递质GABA是由活化的B细胞和血浆细胞合成和分泌的候选信号分子,能够促进单核细胞分化为抗炎巨噬细胞,分泌白细胞介素-10,抑制CD8+T细胞杀伤功能。这说明GABA具有免疫调节功能,可能成为药物靶点。 相关研究内容发表在期刊《Nature》上,题目为“B cell-...
B Schaub,M Campo,H He,... - 《Respiratory Research》 被引量: 228发表: 2006年 Monocytes/macrophages and/or neutrophils are the target of IL-10 in the LPS endotoxemia model IL-10 is a potent regulator of the innate and adaptive immune responses. Several cell types produce IL-10 and its...
In culture, IL-10 suppressed human and murine Tfh cell differentiation by promoting STAT5 phosphorylation. By using an adoptive transfer approach and two-photon live imaging, we found significantly increased numbers of Tfh cells with enhanced T cell homing into B cell follicles in the draining ...
15. B 细胞衍生的 GABA 引发 IL-10 +巨噬细胞以限制抗肿瘤免疫 B cell-derived GABA elicits IL-10+ macrophages to limit anti-tumour immunity 小的、可溶的代谢物不仅是细胞内生化过程中必不可少的中间体,而且在释放到细胞外环境中时也会影响邻近的细胞。在这里,我们将代谢物和神经递质 GABA 鉴定为由活化...