Elisabeth OelmannHarald SteinWolfgang E. BerdelHermann Herbst
研究发现：1 射线照射后胎鼠大脑皮质出现发育不良，并具有一定的癫痫易感性，2 CD形成过程中IL-1β和IL-1R1表达上调，3 干扰IL-1R1的表达可导致胎鼠大脑皮层神经元迁移异常及其导向突起伸展方向紊乱，4 喹硫平可改善CD大鼠髓鞘损伤、促进髓鞘发育，降低其癫痫易感性。本项目从炎症角度阐明CD的发生机制，为CD的...
Immobilized Human IL-1 beta at 10 μg/mL (100 μL/well) can bind Biotinylated Human IL-1R1 with a linear range of 0.002-1 μg/mL.制剂Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.Contact us for customized product form or formulation.储存Store the lyophilized protein at...
The signaling capacity of TRAIL R4 is similar to that of TRAIL R1 and TRAIL R2 with respect to NF-κB activation, but differs in its inability to induce apoptosis. TRAIL R4 retains a C-terminal element containing one third of aconsensus death domain motif. Transient overexpression of ...
Pro-Casp-1(由 pro-Casp-1 编码)由炎症小体激活,将 pro-IL-1β 裂解为具有生物活性的 IL-1β。IL-1β 通过 I 型IL-1受体 (IL-1R1) 以自分泌/旁分泌方式发挥作用[1][2][3]. IL-1β可以调节炎症反应,参与多种细胞活动,包括细胞增殖、分化和凋亡。IL-1β 还对雌性[1][2][3]的生殖起着...
Using a combination of biophotonic imaging, immunofluorescence imaging, and lipid raft density gradient isolation, I demonstrate that both Nox2 and IL-1R1 are constitutively present in lipid raft microdomains on the plasma membrane. Stimulation by IL-1beta induces endocytosis of Nox2 and IL-1R1 ...
Anti-IL-1R1抗体,白介素1受体1抗体Anti-IL-1R2抗体,白介素1受体2抗体Anti-IL1RAPL1抗体,白介素1受体相关蛋白样1前体蛋白抗体Anti-IL1RAPL2抗体,白介素1受体9抗体Anti-IL-1RA抗体,白介素-1受体拮抗剂抗体Anti-IL2 Receptor beta抗体,白介素2受体β链抗体 IL-2RβAnti-IL-20R alpha抗体,白介素20受体...
Interleukin-1beta (IL-1b) contributes to inflammatory hyperalgesia and facilitates heat-induced release of calcitonin gene-related peptide in vitro. Here, we investigated the effects of IL-1? on rat dorsal root ganglia neurons in culture, using noxious heat as a stimulus.After dissociation, the ...
3. Immobilized human IL1B at 10 μg/mL (100 μl/well) can bind human IL1R1, The EC50 of human IL1R1 is 0.48 μg/mL. 4. Measured by its ability to induce Interferon gamma secretion by human natural killer lymphoma NK-92 cells. The ED50 for this effect is 0.4-2 ng/mL. ...