这一切都足以证明IL-7/IL-15组合培养的优越性,但是在免疫细胞因子(IL-2、IFN-γ、TNF-α)或特异性裂解方面没有显著差异。在免疫缺陷的小鼠体内,如图3G所示,用IL-7/IL-15培养扩增的19BB-CAR-T细胞治疗4周后,小鼠体内的肿瘤生长明显受到抑制,小鼠的生存期明显延长。 Fig4:补用IL-7/IL-15培养的19BB-CAR-...
IL-12、IL-15等，表现出了克服实体瘤免疫抑制微环境的能力。因此，将具备重要免疫调节能力的细胞因子（...
重组人IL-15蛋白可刺激小鼠T淋巴细胞CTLL-2 增殖,比活性1×108units/mg (NIBSC代码:95/554) 参考文献: 【1】 Coppola C, Hopkins B, Huhn S, Du Z, Huang Z, Kelly WJ. Investigation of the Impact from IL-2, IL-7, and IL-15 on the Growth and Signaling of Activated CD4+ T Cells. Int ...
图4:重组人IL-15蛋白可刺激小鼠T淋巴细胞CTLL-2 增殖,比活性>5×10⁶IU/mg(NIBSC代码:95/554) 参考文献: 【1】 Coppola C, Hopkins B, Huhn S, Du Z, Huang Z, Kelly WJ. Investigation of the Impact from IL-2, IL-7, and IL-15 on the Growth and Signaling of Activated CD4+ T Cells....
作为适应性免疫系统必需的细胞因子，IL-7对B细胞发育、T细胞发育、增殖和存活至关重要。IL-7及其受体（...
总而言之,与基于IL-2的T细胞生产方案相比,IL-7/IL-15组合在产生CD4+和CD8+T细胞方面似乎并不优越 Selvarajan, V., How, G., Teo, D., Loh, W., & Loo, B. (2021). Effect of IL-2 and IL-7/IL-15 concentration on t cell expansion. Cytotherapy, 23(5), S177....
and are preserved by IL-7 and IL-15. Blood. 2014 Jun 12;123(24):3750-9.【3】 Gong W, Hoffmann JM, Stock S, Wang L, Liu Y, Schubert ML, Neuber B, Hückelhoven-Krauss A, Gern U, Schmitt A, Müller-Tidow C, Shiku H, Schmitt M, Sellner L. Comparison of IL-2 vs IL-7/...
【2】 Xu Y, Zhang M, Ramos CA, Durett A, Liu E, Dakhova O, Liu H, Creighton CJ, Gee AP, Heslop HE, Rooney CM, Savoldo B, Dotti G. Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15. Blood. 2014...
图4:重组人IL-15蛋白可刺激小鼠T淋巴细胞CTLL-2 增殖,比活性>5×106IU/mg(NIBSC代码:95/554) 参考文献: 【1】 Coppola C, Hopkins B, Huhn S, Du Z, Huang Z, Kelly WJ. Investigation of the Impact from IL-2, IL-7, and IL-15 on the Growth and Signaling of Activated CD4+ T Cells. In...
The article investigates the potential therapeutic benefits of interleukin (IL)-7 and IL-15 as vaccine adjuvants in HIV infections using macaque models by researchers from Bethesda, Maryland. The study was based on SIV macaque as a post-exposure vaccination model to assess whether intervention ...