Infiltration, accumulation, and survival of chimeric antigen receptor T (CAR-T) cells in solid tumors is crucial for tumor clearance. We engineered CAR-T cells to express interleukin (IL)-7 and CCL19 (7 × 19 CAR-T cells), as these factors are essential for the maintenance of T-cell zo...
2022年《MOLECULAR CANCER THERAPEUTICS》上发表了文章《Enhanced Antitumor Responses of Tumor Antigen-Specific TCR T Cells Genetically Engineered to Produce IL7 and CCL19》,该文章显示 IL-7 和 CCL19使TCR-T的各方面能力产生质的飞越,...
Moreover, this response is associated with an increase of DC with a capacity of cross presentation to T cells, which is a crucial machinery for the epitope spreading. Reference Adachi K, Kano Y, Nagai T, Okuyama N, Sakoda Y, Tamada K. IL-7 and CCL19 expression in CAR-T cells ...
IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor. Nat Biotechnol. 2018 Apr;36(4):346-351;[6] Tokunaga Y, Sasaki T, Goto S, Adachi K, Sakoda Y, Tamada K. Enhanced Antitumor Responses of Tumor Antigen-Specific TCR T ...
[4] Adachi K, Kano Y, Nagai T, Okuyama N, Sakoda Y, Tamada K. IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor. Nat Biotechnol. 2018 Apr;36(4):346-351.
3、2022年《MOLECULAR CANCER THERAPEUTICS》上发表了文章《Enhanced Antitumor Responses of Tumor Antigen-Specific TCR T Cells Genetically Engineered to Produce IL7 and CCL19》,研究证实IL-7和CCL19在免疫细胞治疗方面具有积极作用,不仅仅体现在CAR-T细胞治疗领域[5],在TCR-T细胞治疗领域[6],也依然有效。我们...
Because CCR7 is an essential chemokine receptor for T-cell homing to secondary lymphoid organs, we evaluated whether the differential expression of CCR7 in CAR-T cells driven by IL-7 and IL-15 modifies trafficking toward lymphoid-specific homing signals, including CCL21 and CCL19. As shown in ...
因此在传统的CD19 CAR-T细胞的基础上联合IL-7和CLL19的功能构建新型的四代CAR-T细胞,能促进 CAR-T细胞对淋巴瘤组织的浸润,累积和存活,进一步增强传统CAR-T的抗肿瘤作用。我们临床研究已经证明表达IL-7和CCL19的CD19 CAR-T细胞(CD19-7×19 CART)相对于传统 CD19 CAR-T能有效杀伤B细胞肿瘤,分泌大量的细胞因...
In LN, RNA transcripts for the chemokines CCL3, CCL19, CCL20, CXCL10 and CXCL13 were significantly upregulated (Figure 3A), suggesting increased recruitment within the LN of CCR5, CCR7, CCR6, CXCR3 and CXCR5 expressing cells. To confirm these findings, we measured cytokine/chemokine changes...
127阳性细胞表达的il-7受体的α链,并且可选地表现出对表达cd127(cd127+细胞)的人t细胞的细胞毒活性,以及(ii)不是il7-r或tslp-r拮抗剂,特别地不是人il-7或人tslp拮抗剂,特别是不抑制由il7诱导的stat5磷酸化和/或不抑制由tslp刺激的血液衍生的人树突细胞产生的tarc(胸腺和激活调节的趋化因子,也称为ccl17...