In vivo neutralization of IL-6 receptors ameliorates gastrointestinal dysfunction in dystrophin-deficient mdx mice. Manning J,Buckley MM,O’’Halloran KD,et al. Neurogastroenterology and motility . 2016Manning J, Buckley MM, O'Halloran KD, O'Malley D. In vivo neutralization of IL-6 receptors ...
We treated systemically mdx mice with low doses (52,5 mg AON / kg) of nanoparticle-AON complexes, and we analyzed the mice 1 and 12 weeks after the end of the treatment. At 1 week after the end of the treatment analysis of mRNA (Nested RT-PCR and Real Time-RT-PCR) has allowed ...
There was no significant improvement in muscle strength nor muscle pathology due to IL-6r mAb treatment in mdx mice. These results showed that instead of reducing inflammation, IL-6 signaling blockade for 5 weeks caused an increase in muscle inflammation, with no significant change in indices ...
Dystrophin/utrophin double-knockout (dKO) mice develop a more severe and progressive muscular dystrophy than the mdx mice, the most common murine model of Duchenne muscular dystrophy (DMD). In particular, dKO mice have smaller body sizes and muscle diameters, and develop progressive kyphosis and ...