慢性肾功能衰竭患者的3个亚组中IL-13浓度均较健康人高(P<0.05),且2类人群中均呈现出细胞因子刺激组较对照组升高,干预组较细胞因子刺激组降低的现象;Western blot结果显示p-STAT6的蛋白水平随时间的延长逐渐增高.结论: 慢性肾衰患者外周血中ILC2的比例升高,同时ILC2内STAT6活化并分泌大量IL-13,介导Th2细胞的...
喘息患儿外周血ILC2及相关细胞因子变化及意义 目的:检测患有喘息性疾病的儿童外周血2型固有淋巴细胞(Group 2 Innate Lymphoid Cells,ILC2)相对含量及ILC2相关细胞因子白细胞介素(Interleukin,IL)-4,白细胞介素-5(I... 金杰 - 《江苏大学》 被引量: 0发表: 2022年 ...
Article Open access 31 August 2023 Activation of ILC2s through constitutive IFNγ signaling reduction leads to spontaneous pulmonary fibrosis Article Open access 14 December 2023 Introduction Idiopathic pulmonary fibrosis (IPF) is a devastating and progressive interstitial lung disease with a median surv...
Type 2 innate lymphoid cells-new members of the "type 2 franchise" that mediate allergic airway inflammation Type 2 innate lymphoid cells (ILC2s) are members of an ILCfamily, which contains NKcells and Rort+ILCs, the latter including lymphoid tissue inducer (LTi) ... Jenny Mjsberg,H Spits...
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Keywords: pancreatic beta cell dysfunction; insulin secretion; interleukin-6; type 2 diabetes; exercise; skeletal muscle; electrical pulse stimulation; organ crosstalk 1. Introduction The pathophysiology of type 2 diabetes (T2D) is incompletely understood, but it is generally accepted that hyperglycemia ...
该研究明确指出,ILC2细胞在三级淋巴结构(TLSs)形成中起到关键作用,而这一过程的核心驱动力正是白细胞介素-33(IL-33)。IL-33通过与ILC2细胞表面的ST2受体结合,激活下游信号通路,促进ILC2的扩增和功能性因子分泌。 研究显示,ILC2在IL-33的刺激下...
in anemic 3.80 pg/mL (0.33-29.70) and non-anemic 2.85 pTg/ambLle(01..2S2e-3r3u.m96)h(e0p.9c2id3in) (aTnabdleIL1)-.6, hematological and iron metabolism parameters in phttp-equiv="content-type"
ILC2s are present in adipose tissue and play a critical role in regulating adipose thermogenesis. However, the mechanisms underlying the activation of adipose-resident ILC2s remain poorly defined. Here, we show that IL-33, a potent ILC2 ... MA Mandell - 《Journal of Experimental Medicine》 被...
Interleukin (IL)-22-producing group 3 innate lymphoid cells (ILC3) promote mucosal healing and maintain barrier integrity, but how microbial signals are in... Randy,S,Longman,... - 《Journal of Experimental Medicine》 被引量: 176发表: 2014年 A major population of mucosal memory CD4+ T cel...