因此,IL-6一个非常优异的CSS程度预测和预后指标。各项研究表明,IL-6的表达与新冠患者严重程度密切相关01于2022年4月2日发表在国际期刊nature/signal transduction and targeted therapy(IF=38.104(2022)),题为 “A genetic variant in IL-6 lowering its expression is...
Gene Expression RegulationPromoter Regions, GeneticEosinophilsEndothelial cells produce immunomodulatory cytokines in response to soluble mediators of inflammatory/immune reactions. We have previously demonstrated that the leukocyte-derived cytokine, oncostatin M (Onco M) can alter endothelial cell morphology, ...
[6] Botelho, Fernando M., et al. "Pulmonary expression of oncostatin M (OSM) promotes inducible BALT formation independently of IL-6, despite a role for IL- 6 in OSM-driven pulmonary inflammation." The Journal of Immunology 191.3 (2013): 1453-1464.[7] Mosley, Bruce, et al. "Dual ...
Cyclosporine A-Mediated IL-6 Expression Promotes Neural Induction in Pluripotent Stem Cells. There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience. Abstract Differentiation of pluripotent s...
IL-6 is an inflammatory cytokine and its overexpression plays an important role in osteoarthritis (OA) pathogenesis. Expression of IL-6 is regulated post-transcriptionally by MCPIP1. The 3′ untranslated region (UTR) of MCPIP1 mRNA harbors a miR-139 ‘se
Cell-Specific Differences in the Regulation of IL-6 Expression by PMA ☆doi:10.1006/bbrc.1999.0899We have studied the regulation of IL-6 expression in human blood monocytes and lymphocytes. \\{LPS\\} and IFN-γ induced IL-6 gene expression with a similar qualitative profile in both cell ...
MethodsRat saphenous vein endothelial cells were cultured and adenovirus vector with IL-6 interference was constructed. Then the DVT model of IL-6 expression inhibition was established by injecting adenovirus containing IL-6 gene into the tail vein.To o...
Because IL-6 expression and release are known to be augmented during exercise in glycogen-depleted animals, CXCL-1 and IL-6 expression were examined after exercise in overnight-fasted mice. We found that fasting significantly augmented serum CXCL-1, and CXCL-1 expression in liver and muscle. ...
[6] Botelho, Fernando M.,et al."Pulmonary expression of oncostatin M (OSM) promotes inducible BALT formation independently of IL-6, despite a role for IL- 6 in OSM-driven pulmonary inflammation." The Journal of Immunology 191.3 (2013): 1453-1464. ...
IL-6 expression was also elevated on the pressure side of a rat OTM model with an SMF. The OTM distance induced by an SMF was significantly decreased after injection of the IL-6 inhibitor tocilizumab. These results imply that SMF promotes osteoclastogenesis by inducing force-loaded PDLSCs to ...