SA–IL-4处理抑制免疫细胞浸润到脊髓并诱导dLNs的免疫抑制环境 分析治疗后脊髓和dLNs中的免疫细胞,发现注射SA–IL-4显著抑制免疫细胞浸润CNS,在脊髓中检测到极少数CD45+免疫细胞,且几乎检测不到Th17细胞,此外,SA–IL-4增加G-MDSCs,减少M-MDSCs,降低了dLNs中Th17 CD4+T细胞的频率,降低了dLNs中M1巨噬细胞的频率...
MDSC: markers, development, states, and unaddressed complexity. Immunity 54, 875–884 (2021). Article CAS PubMed PubMed Central Google Scholar Seita, J. & Weissman, I. L. Hematopoietic stem cell: self-renewal versus differentiation. Wiley Interdiscip. Rev. Syst. Biol. Med. 2, 640–653 ...
Cytokines and Receptors in Angiogenesis Cytokines and Receptors in Tfh Cell Differentiation and Function Macrophage Activation Markers Microglia Activation Markers Myeloid-derived Suppressor Cells (MDSC) Receptors in the Jak/STAT Pathway Regulatory T Cells (Tregs) ...
MDSC-induced Immune Suppression Myeloid-Derived Suppressor Cells Neurodegeneration Neuroinflammation NFAT Signaling and Lymphocyte Interactions Regulatory T Cells T Follicular Helper Cell Pathway Th17 Biology TH2 Pathway (Humoral Immune Response) Pages Quality Control ELISA Kits and Sets Related...
分析治疗后脊髓和dLNs中的免疫细胞,发现注射SA–IL-4显著抑制免疫细胞浸润CNS,在脊髓中检测到极少数CD45+免疫细胞,且几乎检测不到Th17细胞,此外,SA–IL-4增加G-MDSCs,减少M-MDSCs,降低了dLNs中Th17 CD4+T细胞的频率,降低了dLNs中M1巨噬细胞的频率并增加了...
MDSC-induced Immune Suppression Myeloid-Derived Suppressor Cells Neurodegeneration Neuroinflammation NFAT Signaling and Lymphocyte Interactions Regulatory T Cells Stem Cells and Development T Follicular Helper Cell Pathway TH2 Pathway (Humoral Immune Response) Pages Quality Control Multicolor Stain...
高表达IL4I1的肿瘤中免疫抑制性细胞富集,比如髓源抑制性细胞(MDSC)和Treg细胞。多组学因子分析也证实了这一点,含有IL4I1的模块与MDSC和Tregs密切相关。CLL是一种表达IL4I1的B细胞淋巴瘤,CLL复发的患者中,IL4I1表达与AHR活性相关,说明侵袭性CLL可用于IL4I1的研究。研究者研究了侵袭性CLL小鼠模型(TCL1 AT)...
Cytokines and Receptors in Tfh Cell Differentiation and Function Macrophage Activation Markers Microglia Activation Markers Myeloid-derived Suppressor Cells (MDSC) Receptors in the Jak/STAT Pathway Regulatory T Cells (Tregs) T Cell Cytokine Signaling ...
A study in mice identified an aptamer targeting CD124 that depleted tumor-promoting myeloid-derived suppressor cells (MDSCs) and could help treat breast cancer. Further details on the research, next steps and licensing status are discussed in the article.SciBX: Science-Business eXchange...
Fc–IL-4 enriches functional CD8+TTEcells Interleukin-4 (IL-4), a prototypical type 2 cytokine, has been reported to prolong the survival of T and B lymphocytes15,16. Here we proposed that IL-4 could rejuvenate the tumour-infiltrating exhausted T cells for enhanced cancer immunotherapy. We...