[17].Hallett MA, Venmar KT, Fingleton B. Cytokine stimulation of epithelial cancer cells: the similar and divergent functions of IL-4 and IL-13. Cancer Res. 2012 Dec 15;72(24):6338-43. doi: 10.1158/0008-5472.CAN-12-3544. Epub 2012 Dec 7. PMID: 23222300; PMCID: PMC3531868. ...
2001. B cells activated via CD40 and IL-4 undergo a division burst but require continued stimulation to maintain division, survival and differentiation. Eur. J. Immunol. 31: 1150 -1159.Rush JS, Hodgkin PD. 2001. B cells activated via CD40 and IL-4 undergo a division burst but require ...
Interleukin-4 (IL-4), also known as B cell-stimulatory factor-1, is a pleiotropic cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells and produced by by mast cells, activated T cells and bone marrow stromal cells.Mature human IL-4 shares 55%, 39% ...
2024年9月25日,相关研究以“A type 2 cytokine Fc–IL-4 revitalizes exhaustedCD8+T cells against cancer”为题在线发表在Nature,EPFL唐力教授、浙江大学药学院郭雨刚研究员以及耶鲁大学樊荣教授为论文的共同通讯作者。值得一提的是,由...
Participates in at least several B-cell activation processes as well as of other cell types.IL-4 is primarily expressed by Th2-biased CD4+T cells,mast cells,basophils,and eosinophils.It promotes cell proliferation,survival,and immunoglobulin class switch to IgG1 and IgE in mouse B cells,...
2024年9月25日,相关研究以“A type 2 cytokine Fc–IL-4 revitalizes exhaustedCD8+T cells against cancer”为题在线发表在Nature,EPFL唐力教授、浙江大学药学院郭雨刚研究员以及耶鲁大学樊荣教授为论文的共同通讯作者。值得一提的是,...
Interleukin-4 (IL-4) is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. IL-4 is produced by mast cells, T cells, and bone marrow stromal cells. IL-4 regulates the differentiation of naive CD4+ T cells into help...
Interleukin-4 (IL-4) is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. IL-4 is produced by mast cells, T cells, and bone marrow stromal cells. IL-4 regulates the differentiation of naive CD4+ T cells into help...
type II receptor also transduces IL-13 mediated signals. IL-4 is primarily expressed by Th2-biased CD4+ T cells, mast cells, basophils, and eosinophils (1, 2). It promotes cell proliferation, survival, and immunoglobulin class switch to IgG4 and IgE in human B cells, acquisition of the ...
Synonyms: Interleukin-4; IL-4; B-Cell Stimulatory Factor 1; BSF-1; Binetrakin; Lymphocyte Stimulatory Factor 1; Pitrakinra; IL4 Species: Human Source: HEK 293 Biological Activity: The cell proliferation assay using TF-1 human erythroleukemic cells has an ED50 value of 0.01-0.05 ng/mL. Cyn...