Neutralizing monoclonal antibody against human IL-33 Anti-hIL-33-IgG (clone 19G8) is a monoclonal antibody (mAb) specific for human interleukin 33 (hIL-33). It is produced in hybridomas and purified by affinity chromatography. This antibody has been selected for its ability to efficiently neu...
An isolated human anti-IL-33 neutralizing monoclonal antibody or fragment thereof, wherein the antibody having an antagonistic action on IL-33, in particular the amino acid sequence of the framework region is the amino acid sequence of the germline amino acid sequence or a combination thereof To...
IL-33-mediated thymic involution induces naive T cell aging and impairs host control of infection Next, we explored the consequences of IL-33-induced thymic involution on T cell immunity during severe infection. Concomitant with restored thymic phenotype and function, the TCR avidity of naive T ce...
IL-33 or ST2L-neutralizing antibody treatment attenuates IL-33-mediated NF-κB activation and M2 macrophage polarization To abolish the pro-tumor effects of IL-33/ST2L signal in TME, we generated IL-33-neutralizing (α-IL-33) and ST2L-neutralizing antibody (α-ST2L) (Supplementary Fig. S3...
［Key words ］IL -33；Therapeutic target ；Neutralizing antibody ；Drugs ；Inflammation -related diseases 细胞因子IL -1超家族通过调节宿主防御、炎症和损伤在先天性和适应性免疫中起关键作用［1］。IL -33是IL -1家族的非常规新成员，属于损伤相关分子模式（damage -associated molecular patterns ，DAMP ），...
Generation of tozorakimab, a potent, high‑affinity IL‑33 neutralizing antibody. The affinity of the lead mAb (33v20064) for IL-33red was at least 100,000-fold lower than the affinity of sST2 (< 90 fM) for IL-33red. Therefore, comprehensive affinity maturation was undertaken ...
However, the administration of IFN-γ-neutralizing antibody did not significantly change the viral load on CNS [27]. Thus, it seems that IFN-γ production on CNS could act by breaking the BBB allowing or facilitating the infiltration and activation of resident cells such as microglia. ...
IL-33 neutralizing antibody Morphine-induced hyperalgesia and analgesic tolerance / SNI / Gout arthritis / OA / Urushiol-induced ACD model / DNFB-induced ACD [9], [23], [42], [52], [69], [85] Il33-/- Morphine-induced hyperalgesia and analgesic tolerance / Gout arthritis / OA / HDM-...
Using a broad-spectrum inhibitor of MMPs (batimastat) and an EGFR neutralizing antibody, we further demonstrated the role of MMPs-dependent shedding of EGFR ligands for Der p-induced IL-33 expression. Among MMPs, TACE, also called ADAM17 (ADAM metallopeptidase domain 17), is preferentially ...
We then examined the potential therapeutic effect of neutralizing IL-33 in the surviving sepsis mice using the IL-33 decoy receptor, soluble ST2 (sST2). Treatment of WT mice with sST2 significantly protected sepsis-surviving mice from the following infection with L. pneumophila (Fig. 1h). Ther...