Neutralizing monoclonal antibody against human IL-33 Anti-hIL-33-IgG (clone 19G8) is a monoclonal antibody (mAb) specific for human interleukin 33 (hIL-33). It is produced in hybridomas and purified by affinity chromatography. This antibody has been selected for its ability to efficiently neu...
An isolated human anti-IL-33 neutralizing monoclonal antibody or fragment thereof, wherein the antibody having an antagonistic action on IL-33, in particular the amino acid sequence of the framework region is the amino acid sequence of the germline amino acid sequence or a combination thereof To...
Substantial evidence shows that the alarmin IL-33 was strongly produced by inflammation-damaged tissues in severe infectious diseases such as schistosomiasis and sepsis25,26,27. As expected, our results showed that the level of full-length or short-form of IL-33 was markedly elevated in the live...
IL-33 or ST2L-neutralizing antibody treatment attenuates IL-33-mediated NF-κB activation and M2 macrophage polarization To abolish the pro-tumor effects of IL-33/ST2L signal in TME, we generated IL-33-neutralizing (α-IL-33) and ST2L-neutralizing antibody (α-ST2L) (Supplementary Fig. S3...
［Key words ］IL -33；Therapeutic target ；Neutralizing antibody ；Drugs ；Inflammation -related diseases 细胞因子IL -1超家族通过调节宿主防御、炎症和损伤在先天性和适应性免疫中起关键作用［1］。IL -33是IL -1家族的非常规新成员，属于损伤相关分子模式（damage -associated molecular patterns ，DAMP ），...
a protein produced by many cell types that blocks receptor binding through competitive inhibition. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions, giving IL-RA or IL-1 beta neutralizing antibodies potential therapeutical value. The NJTEN3 anti...
Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value. 仅用于科研。不用于诊断过程。未经明确授权不得转售。相关产品 ELISA ELISA 封闭液 ELISA 底物 同型对照 Catalog # 37515 Thermo Scientific™...
host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic ...
[20] West, Nathaniel R., et al. "Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease." Nature medicine 23.5 (2017): 579-589.[21] Ito, Hiroaki. "IL-6 and Crohn's disease." Current Drug ...
Using a broad-spectrum inhibitor of MMPs (batimastat) and an EGFR neutralizing antibody, we further demonstrated the role of MMPs-dependent shedding of EGFR ligands for Der p-induced IL-33 expression. Among MMPs, TACE, also called ADAM17 (ADAM metallopeptidase domain 17), is preferentially ...