Elevated IL-18 levels are associated with autoimmune disease, but may be balanced by binding to IL-18 binding protein (IL-18BP), which along with IL-18 neutralizing antibodies, are being examined in clinical trials (6,7). Okamura, H. et al. (1995) Nature 378, 88-91. Ushio, S. et...
The C57BL/6 female mice were mated with the BALB/c male mice, the anti-IL-18 neutralizing antibody was administered intraperitoneally, and the placenta and birth weight were measured. The pregnant uteri were analyzed using flow cytometry, western blotting, and immunofluorescence staining. The ...
but does not recruit IL-18 R beta or induce signaling (9). IL-1F7 binds IL-18 BP and enhances its neutralizing effect on IL-18 activity (9). IL-18 synergizes with other cytokines to activate NK, Th1, and Th17 cells and to increase the production of IFN-gamma (1, 5, 10, 11, ...
PEC anticryptococcal activity was mediated by IFN-gamma and NO production, since it was completely inhibited by a neutralizing anti-IFN-gamma monoclonal antibody (MAb) and N(G)-monomethyl-L-arginine, a competitive inhibitor of NO synthesis, respectively. To identify the IFN-gamma-producing cells ...
(Ig)-like C2-type domain while isoforms b and d lack a complete Ig domain. The complete Ig domain has been shown to be essential to the binding and neutralizing properties of the binding proteins. Two isoforms of mouse IL18 BP (c and d) containing the complete Ig domain have also been...
IL-18BP and anti-IL-18 antibody have been used to neutralize IL-18 and treat these diseases. Novick et al.23 summarized 33 disease models in which inhibition of IL-18 activity by administration of either neutralizing anti-IL-18 antibodies or IL-18BP resulted in a reduction of disease ...
GM-CSF in tumor tissues. Taken together, these results suggest that RdB/IL-12/IL-18 administered intratumorally may be competent at killing the tumor cells, as well as amplifying production of cytokines, by continuously replicating in tumor cells regardless of Ad-specific neutralizing antibody ...
IL-1F7 binds IL-18 BP and enhances its neutralizing effect on IL-18 activity (9). IL-18 synergizes with other cytokines to activate NK, Th1, and Th17 cells and to increase the production of IFN-gamma (1, 5, 10-12). IL-18 can also promote Th2 cytokine release which reduc...
to IL-18 R alpha but does not recruit IL-18 R beta or induce signaling (9). IL-1F7 binds IL-18 BP and enhances its neutralizing effect on IL-18 activity (9). IL-18 synergizes with other cytokines to activate NK, Th1, and Th17 cells and to increase the...
(Ig)-like C2-type domain while isoforms b and d lack a complete Ig domain. The complete Ig domain has been shown to be essential to the binding and neutralizing properties of the binding proteins. Two isoforms of mouse IL18 BP (c and d) containing the complete Ig domain have also been...