Gene expressionIL-23 receptorARMS-PCRThrough investigating genetic variations, it has been demonstrated that single nucleotide polymorphisms (SNPs) in the IL-23 receptor (IL23R) gene have a critical role in the pathophysiology of ankylosing spondylitis (AS). Here, we investigated whe...
产品名称:人白介素23受体(IL-23R)ELISA试剂盒免费代测 特强 英文名称:Humaninterleukin-23receptor(IL-23R)ELISAkit 检测方法:酶联免疫法 品牌:佰利莱 货号:BLL-R4310E 检测指标:IL-23R 标记物:HRP标记物 应用:定性/定量/酶活检测 贮藏条件:2-8℃ 有效期:6个月 种属:大鼠、小鼠、人、鸡、犬、鱼、乌龟...
Th17 cells require IL-23 receptor (IL-23R) signaling to become pathogenic. The transcriptional mechanisms controlling the pathogenicity of Th17 cells and IL-23R expression are unknown. Here, we demonstrate that the canonical Notch signaling mediator RBPJ is a key driver of IL-23R expression. In ...
The human IL-23 receptor rs11209026 A allele promotes the expression of a soluble IL-23R-encoding mRNA species. Authors - Raymond YYu View Article human Sci Rep Functional defects in CD4+ CD25high FoxP3+ regulatory cells in ankylosing spondylitis. Authors - HuifangGuo View Article See more ci...
Recombinant Human Interleukin-23 Receptor is produced by our Mammalian expression system and the target gene encoding Gly24-Asp353 is expressed with a Fc tag at the C-terminus. 实验案例 相关产品
本研究所选定的研究对象之一IL-23主要是经抗原提呈细胞所分泌的一种细胞因子,同时其受体(Interleukin-23receptor,IL-23R)为一种促红细胞生成素受体家族成员,当IL-23与IL-23R产生结合后即可发挥生物学效应,如该效应可促进I?Bα降解并将NF-?B诱导激活;也有研究者发现当IL-23与IL-23p19结合后还可通过蛋白酪氨酸...
et al. RBPJ Controls Development of Pathogenic Th17 Cells by Regulating IL-23 Receptor Expression. Cell Rep. 16, 392–404 (2016). Article CAS PubMed PubMed Central Google Scholar Mukherjee, S., Schaller, M. A., Neupane, R., Kunkel, S. L. & Lukacs, N. W. Notch ligand Dll4 ...
Results Insulin Stimulates IL-23 mRNA Expression in Human Adipocytes As shown in Figure 1, insulin induced a dose-dependent increase in the expression of IL-23 mRNA in human adipocytes in vitro with a 1.3- and 1.9-fold increase of IL-23 mRNA expression at 0.1 (P<0.05) and 5 μM (P<...
HEK-Blue™ IL-23 cells detect human (h) and murine (m) IL-23 (see figures). Of note, these cells also respond to h/mIL‑27, another STAT3-signaling cytokine. Furthermore, due to the endogenous expression of the interferon-α/β receptor (IFNAR), these cells respond to hIFN-β (...
Furthermore, Stat3 inhibits NF-κB/c-Rel-dependent IL-12/p35 gene expression in tumorassociated dendritic cells. Tumor-associated regulatory T cells (Treg) express IL-23 receptor (IL-23R) which activates Stat3 in this cell type, leading to upregulation of the Treg-specific transcription factor,...