The IL-23/IL-17 axis is the primary signaling pathway for cellular and molecular alterations in Ps. Objective: This study aimed to investigate the serum levels of interleukin-23 (IL-23) and its receptor (IL-23R) expression in patients with Ps and psoriatic arthritis (PsA...
产品名称:人白介素23受体(IL-23R)ELISA试剂盒免费代测 特强 英文名称:Humaninterleukin-23receptor(IL-23R)ELISAkit 检测方法:酶联免疫法 品牌:佰利莱 货号:BLL-R4310E 检测指标:IL-23R 标记物:HRP标记物 应用:定性/定量/酶活检测 贮藏条件:2-8℃ 有效期:6个月 种属:大鼠、小鼠、人、鸡、犬、鱼、乌龟...
et al. RBPJ Controls Development of Pathogenic Th17 Cells by Regulating IL-23 Receptor Expression. Cell Rep. 16, 392–404 (2016). Article CAS PubMed PubMed Central Google Scholar Mukherjee, S., Schaller, M. A., Neupane, R., Kunkel, S. L. & Lukacs, N. W. Notch ligand Dll4 ...
infection. RTECs respond to IL-23 by increasing IL-23R expression followed by signaling to promote local kidney inflammation80. Given that IL-23 levels (IL23 p19) are abundant in kidneys during disseminated candidiasis (Fig. 6e) we tested whether IL-23 signaling will reduce ferroptotic cell ...
while the IL-23R chain is unique to the IL-23 receptor complex. IL-23R signaling occurs through the Jak/STAT pathway and results in RORgammat expression, which promotes maintenance and proliferation of T helper 17 (Th17) cells. Dendritic cells and macrophages produce IL-23 in respon...
gene expression guselkumab psoriasis Psoriasis Area and Severity Index serum skin T cell TH17 Abbreviations used AE Adverse event DC Dendritic cell IL-12Rβ1 IL-12 receptor β1 IL-23R IL-23 receptor KRT16 Keratin 16 LCN2 Lipocalin 2 PASI Psoriasis Area and Severity Index PASI 75 75% improveme...
37, 38, 39 Several patients with IL-12Rβ1 deficiency due to a lack of surface receptor expression were previously shown not to respond to IL-23.25,40 We therefore stimulated PHA-T-cell blasts with various doses of IL-23 (5 pg/mL to 500 ng/mL). Cells from C+ produced IFN-γ in...
IL-23 induces receptor activator of NF-κB ligand expression on CD4+ T cells and promotes osteoclastogenesis in an autoimmune arthritis models. J. Immunol. 181, 1507–1518 (2008). Article CAS PubMed Google Scholar Pöllinger, B. et al. TH17 cells, not IL-17+γδ T cells, drive ...
白介素(IL)-33是2005年发现的ST2(IL-1 receptor family member suppression of tumorigenicity 2)的配体,是IL-1家族新成员[1],其基因序列和结构与IL-1β、IL-18相似,促使肥大细胞、淋巴细胞、嗜酸性粒细胞产生Th2类细胞因子,在炎症、感染、自身免疫性...
The extracellular region will still likely to interact with the IL-23 ligand, but the normal downstream signaling activity will be halted due to the truncation. These two variant forms may encode dominant negative variants of the IL-23 receptor. It seems the expression of such truncated proteins...