Interleukin-2 receptor subunit alpha (IL2RA) is a single-pass type I membrane protein, contains 2 Sushi (CCP/SCR) domains. The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. ...
Nikaido, T., et al (1984).Molecular cloning of cDNA encoding human interleukin-2 receptor. Nature 311,631–635. Sharon, M., et al. (1986).Novel interleukin-2 receptor subunit detected by cross-linking underhigh-affinity conditions. Science 234, 859–863. ...
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The IL-2 variants may have reduced ability in binding to or activating IL-2Rα. The IL-2 variants may retain the ability in binding to or activating IL-2Rβ and/or IL-2Rβγ. In addition, the IL-2 variants may have decreased Treg activity but maintain the capacity to activate NK ...
英文名称:Human Interleukin 2 Receptor Alpha(IL-2Rα) ELISA Kit 用途:科研实验 品牌:科博瑞 包装规格:96T/48T 标记物:HRP标记物 样本:血清,血浆,唾液,尿液,组织,细胞上清,裂解液等 检测方法:酶联免疫法 应用:详见说明书 检测限:详见说明书 货号:KBR-hlk1244 ...
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IL-2 R beta (CD122) and gamma c (IL-2 R gamma /CD132) dimerize to form a constitutively expressed intermediate affinity IL-2 receptor (5, 6). By itself, IL-2 R alpha binds IL-2 with low affinity. It associates with IL-2 R beta and gamma c to generate a ternary high affinity...
ternary high affinity IL-2 receptor complex. A soluble form of IL-2 R alpha can be generated by proteolytic cleavage of the cell surface receptor, rendering the T cell unresponsive to IL-2. Increased serum levels of soluble IL-2 R alpha are found in some cancers and immune disorders. IL...
蛋白别名 :CD25, IL-2 receptor subunit alpha, IL-2-RA, IL-2R subunit alpha, IL2-RA, TAC antigen, p55, IL 2 RA, IL 2 receptor, IL 2R, IL 2R subunit alpha, IL2 RA, interleukin-2 receptor alpha, Interleukin2 receptor subunit alpha, sIL 2R, soluble IL 2 receptor, IL2 RA antibody...
IL-2R alpha嵌合体抗体 Basiliximab/巴利昔单抗/舒莱 Novartis 预防首次肾移植术后的急性器官排斥 国内注册号:S20171040 非阻断性抗体 RG6292 非阻断性CD25抗体,选择性清除Treg。 喵评:以IL-2/IL-2R的经典传奇,开启2021-2030新的十年。 参考文献