1促进NK细胞扩增和活化：IL-2/21Soiffer RJ等自1996年起即报道IL-2低剂量持续输注和间歇给药对转移癌患者的CD56+NK细胞有明显扩增效果。大部分NK细胞表面具有IL-2中亲和性受体，IL-2诱导NK的杀伤活性约需18～24小时。此外，IL-2还可诱导NK细胞的增殖，一般在刺激后3～4天开始发生增殖，其机理为IL-2可诱导...
白细胞介素是一组由多种类型细胞分泌的能调节细胞生长、分化和免疫活性的细胞因子,其中多数与NK细胞关系密切,或直接参与NK细胞的调控,或通过影响其它免疫细胞间接调节NK细胞的功能。白细胞介素如IL-2、IL-15和IL-18等被认为是刺...
Expansion and manipulation of natural killer cells in patients with metastatic cancer by low-dose continuous infusion and intermittent bolus administration of interleukin 2. Clin Cancer Res. 1996 Mar;2(3):493-9. PMID: 9816195 Sharma R, Das A. IL-2 mediates NK cell proliferation but not ...
综上所述,本研究揭示了短IL-18通过激活NK细胞抑制肿瘤生长的独特机制,为肿瘤免疫治疗提供了新的靶点和策略。 文中使用的NCAM1/CD56兔多抗,货号:14255-1-AP,来源于Proteintech。 原文链接:cell.com/cell-stem-cell00412-0 来自瑞典的Ning Xu Landén团队和中国医学科学院皮肤病研究所的李冬青团队在《Cell Stem Ce...
二、NK培养试剂盒套装 ►NK总细胞扩增变化 ►NK细胞活率变化 ►NK细胞扩增比例 参考文献: Soiffer RJ, Murray C, Shapiro C, Collins H, Chartier S, Lazo S, Ritz J. Expansion and manipulation of natural killer cells in patients with metastatic cancer by low-dose continuous infusion and interm...
IL‐12/18‐preactivated donor NK cell infusion may be an effective and safe adoptive therapy after allo‐HSCT.doi:10.1002/eji.201747177Yuan SongBo HuYonghao LiuZiqi JinYinsheng ZhangDandan LinYing ZhuLei LeiHuanle GongYu MeiJohn Wiley & Sons, LtdEuropean Journal of Immunology...
IL-18 acts on non-polarized T cells, NK cells, NKT cells, B cells, dendritic cells, and macrophages. In the presence of IL-12, shown to increase the expression of the transducing chain of the IL-18 receptor, IL-18 induces the production IFN-γ. It induces chemokines and cell adhesion...
NK cell Research topic(s) CP: Immunology CP: Microbiology Introduction Interleukin-18 (IL-18) is a member of the IL-1 family that was identified based on its ability to induce natural killer (NK) and T cell production of interferon (IFN)-γ and promote Th1 immunity.1,2 In current model...
IFN-γ activates macrophages, enhances NK activity and B cell maturation, proliferation and Ig secretion, induces MHC class I and II antigens, and inhibits osteoclast activation. IL-18 acts on T helper type-1 (Th1) T cells and in combination with IL-12 strongly induces them to produce IFN...
Ex vivo expansion of NK cells. In concert with IL-2, IL-15, IL-12 and IL-21, IL-18 is a key player in the priming, expansion and survival of NK cells2, 3, 4. Optimization of ex vivo manufacturing protocols for adoptive cell transfer. Studies in animal models have demonstrated that...