近年来获批的代表性药物包括:2020年1月,FDA批准帕博利珠单抗(“K药”)作为一种单药疗法,用于治疗不符合或已选择不进行膀胱切除术(切除膀胱)的卡介苗(BCG)无应答、高风险、伴CIS、伴或不伴乳头状肿瘤的NMIBC患者。2022年12月,FDA批准Ferring的基因疗法nadofaragene firadenovec-vncg(商品名为Adstiladrin)上市,用于...
IL-15 基因功能 The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same rec...
9.Evans R, Fuller J A, Christianson G, et al. IL-15 Mediates Anti-tumor Effects after Cyclophosphamide Injection. Cellular Immunology, 1997, 179(1): 66-73. 10.Hoyos V, Savoldo B, Quintarelli C, et al. Engineering CD19-specific T lymphocytes wit...
鸡ＩＬ １５基因的克隆及序列分析 张 凤，田艳花，牛四坤，台晶杰，刘文娟通信作者 山西药科职业学院，山西太原０３００３１ 摘 要 目的 利用基因工程的方法，将鸡白细胞介素１５（ＣｈＩＬ １５）基因在原核表达系统中进行表达，为ＣｈＩＬ １５的应用提供科学依据。方法 根据美国国家生物信息中心（ＮＣＢＩ...
10.Hoyos V, Savoldo B, Quintarelli C, et al. Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety[J]. Leukemia, 2010, 24(6): 1160-1170. 11.ht...
基于这些数据，探索下肿瘤细胞递送基因IL-15是否能引发抗肿瘤免疫反应，并能增强K2-Fc的免疫刺激作用。近期，来自比利时布鲁塞尔自由大学的研究人员在Nature子刊Science Reports期刊发表 "In vitro modelling of local gene therapy with IL-15/IL-15Rα and a PD-L1 antagonist in melanoma reveals an interplay ...
基因序列:NCBI_Gene:25670 蛋白序列:UniProtKB:P97604 大鼠Rat Il15 靶点分子功能(预测) Predicted to enable cytokine activity. Involved in several processes, including cellular response to vitamin D; positive regulation of tyrosine phosphorylation of STAT protein; and skeletal muscle atrophy. Located in ce...
概述 Human Interleukin-15 (IL-15) is expressed by the IL15 gene located on the chromosome 4. It shares approximately 97 % and 73 % sequence identity with simian and murine IL-15, respectively. Both human IL-15 and simian IL-15 are active on murine cells. IL-15 is secreted by mononucl...
Hsu C, Hughes MS, Zheng Z, Bray RB, Rosenberg SA, Morgan RA (2005) Primary human T lymphocytes engineered with a codon-optimized IL-15 gene resist cytokine withdrawal-induced apoptosis and persist long-term in the absence of exogenous cytokine. J Immunol 175...
Background Human Interleukin-15 (IL-15) is expressed by the IL15 gene located on the chromosome 4. It shares approximately 97 % and 73 % sequence identity with simian and murine IL-15, respectively. Both human and simian IL-15 are active on murine cells. IL-15 is secreted by mononuclear...