2. The method of claim 1, wherein said disease state selected from the group consisting of: inflammation, autoimmune disease, cartilage inflammation, and/or bone degradation, arthritis, rheumatoid arthritis, juvenile arthritis, juvenile rheumatoid arthritis, pauciarticular juvenile rheumatoid arthritis, po...
There are various pathways involved in hepcidin regulation, including TfR2/HFE, BMP/SMAD, and IL-6/STAT3 [4,9,26]. Bone morphogenetic protein 6 (BMP6) can bind to the BMP receptor in conjunction with haemojuvelin (HJV), resulting in SMAD phosphorylation in downstream signalling, which stimu...