小鼠角化细胞源性细胞因子(keratinocyte-derived Cytokine,KC),也称为CXCL1或N51,最初是从成纤维细胞中作为PDGF诱导的即早基因被鉴定出,其编码一个约8kDa的分泌蛋白。根据小鼠KC的蛋白质序列,其属于alpha(CXC)趋化因子家族。除有丝分裂原活化的成纤维细胞外,KC还能在细菌或LPS刺激的腹膜及肺巨噬细胞、内皮细胞、...
Qian Liu et al,The CXCL8-CXCR1/2 pathways in cancer,Cytokine Growth Factor Rev . 2016 Oct;31:61-71 Carlos Alfaro et al,Interleukin-8 in cancer pathogenesis, treatment and follow-up,Cancer Treat Rev . 2017 Nov;60:24-31. 识别微信二维码,添加生...
乳腺癌化疗,当IL-8低于16.6pg/ml 中位总体存活 47.5月,大于16.6 pg/ml,则降至20.5月。 文献1 血液IL-8水平与免疫检查点抑制剂治疗过程中,肿瘤响应及复发动态趋势更加一致。 文献8 靶向IL-8/IL-8R的药物 IL-8/IL-8R通路靶向药物(文献7) 在研药物概况 喵评:IL-8是一个趋化因子,参与形成肿瘤微环境的免...
乳腺癌化疗,当IL-8低于16.6pg/ml 中位总体存活 47.5月,大于16.6 pg/ml,则降至20.5月。 文献1 血液IL-8水平与免疫检查点抑制剂治疗过程中,肿瘤响应及复发动态趋势更加一致。 文献8 靶向IL-8/IL-8R的药物 IL-8/IL-8R通路靶向药物(文献7) 在研药物概况 喵评:IL-8是一个趋化因子,参与形成肿瘤微环境的免...
peptide; NAF; NAP 1; NAP-1; NAP1; Neutrophil activating factor; Neutrophil activating peptide 1; Neutrophil activating protein 1; Neutrophil-activating factor; Neutrophil-activating protein 1; Protein 3 10C; Protein 3-10C; SCYB 8; SCYB8; Small inducible cytokine subfamily B member 8; T cell ...
[10] Hodge G, Nairn J, Holmes M, et al. Increased intracellular T helper 1 proinflammatory cytokine production in peripheral blood, bronchoal- veolar lavage and intraepithelial T cells of COPD subjects. Clin Exp Immunol 2007;150(1):22–29 ...
Chemotactic cytokine (IL 8 and MCP 1) gene expression by human whole blood. Immunol. Invest. 20, 387 394.Ham JM, Kunkel SL, Dibb CR, Standiford TJ, Rolfe MW, Strieter RM: Chemotactic cytokine (IL-8 and MCP-1) gene expression by human whole blood. Immunol Invest 1991, 20:387-394...
其他报告已证明IL-8-中和抗体在动物皮肤病、关节炎及肾小球性肾炎模型中相似的良好效应(Akahoshi等,Lymphokine and Cytokine Res.,1994,13,113-116;Nishimura等,J.Leukoc.Biol.,1997,62,444-449;Wada等,J.Exp.Med.,1994,180,1135-1140)。除此之外,去除编码与人类2型受体(CXCR2)同源的鼠科IL-8受体的基因...
Cytokine (IL-8, IL-6, TNF-α) and soluble TNF receptor-I release from human peripheral blood mononuclear cells after respiratory syncytial virus infection 来自 EBSCO 喜欢 0 阅读量: 48 作者:R Arnold,B König,H Galatti,H Werchau,W König ...
[8]Dinarello, C. A. (2010). IL-1: Discoveries, controversies and future directions. European Journal of Immunology, 40(3), 599–606. [9]J. Palomo et al., The interleukin (IL)-1 cytokine family – Balance between agonists and antagonists in inflammatory diseases, Cytokine (2015). ...