白介素-6(IL-6)是一种非冗余细胞因子,参与T辅助细胞17(TH17)细胞的分化。幼稚T细胞通过其膜结合IL-6受体(IL-6R)感知IL-6; IL-6阻止了转化生长因子-β(TGFβ)介导的FOXP3的诱导,并促进了视黄酸受体相关的孤儿核受体γ(ROR-γt)(TH17的主要转录因子)的表达细胞。然而,仅当树突状细胞(DC)将IL-6转染至T...
sIL-6R不仅可以结合其配体IL-6，而且IL-6和sIL-6R复合物可以结合并激活不携带膜结合IL-6R的细胞上的gp130。这个过程被称为IL-6反式信号传导，从而增强了IL-6靶细胞谱，这解释了IL-6的多效性功能。反式呈递 树突状细胞（DC）与抗原相互作用之后，已经与DC中的IL-6R细胞内结合的IL-6，被反式递呈到质膜上。
[3]Mihara M, Hashizume M, Yoshida H, et al. IL-6/IL-6 receptor system and its role in physiological and pathological conditions[J]. Clin Sci(Lond), 2012, 122(4): 143-59. [4]Calabrese LH, Rose-John S. IL-6biology: implications for clinical targeting in rheumatic disease[J]. Nat ...
白介素-6(IL-6)是一种非冗余细胞因子,参与T辅助细胞17(TH17)细胞的分化。幼稚T细胞通过其膜结合IL-6受体(IL-6R)感知IL-6; IL-6阻止了转化生长因子-β(TGFβ)介导的FOXP3的诱导,并促进了视黄酸受体相关的孤儿核受体γ(ROR-γt)(TH17的主要转录因子)的表达细胞。然而,仅当树突状细胞(DC)将IL-6转染至T...
[5] Mudter J, Neurath MF. Il-6 signaling in inflammatory bowel disease: pathophysiological role and clinical relevance[J]. Inflamm Bowel Dis. 2007;13(8):1016-1023. [6] Weber R, Groth C, Lasser S, et al. IL-6 as a major regulator of MDSC activity and possible target for cancer imm...
文献题目:Role of IL-6 and IL-6 targeted therapy in systemic lupus erythematosus 研究人员:Desh Nepal,et al 研究单位: 美国威斯康辛州,密尔沃基市威斯康辛医学院医学系风湿病科。 发表时间: 2023.12 期刊名称:Rheumatology (Oxford) 影响因子:5.5
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[6] Botelho, Fernando M., et al. "Pulmonary expression of oncostatin M (OSM) promotes inducible BALT formation independently of IL-6, despite a role for IL- 6 in OSM-driven pulmonary inflammation." The Journal of Immunology 191.3 (2013): 1453-1464.[7] Mosley, Bruce, et al. "Dual ...
Interleukin 6 (IL-6) is produced by adipose tissue under non-inflammatory conditions1,2and has been shown to be mildly elevated in obesity. Similar to leptin, serum IL-6 levels correlate with Body Mass Index (BMI).1-3IL-6 knockout (IL-6 K/O) mice have been shown to develop mature-...