1. Sujin Kang et al. Historical overview of the interleukin-6 family cytokine.2020. J. Exp. Med. 2020 Vol. 217 No. 52. 《现代临床医学免疫学检验技术》，李天星，陈建明，蒲晓允，赵树铭，2014年第一版3. S. Kaur et al. A Panoramic Review of IL-6: Structure, Pathophysiological Roles and ...
图6.肌肉源性IL-6的预测NAFLD缓解模型[7] ⑦COVID-19治疗 在新冠病毒(SARS-CoV-2)感染的治疗中,IL-6抑制剂有时被用于减轻病情的炎症和细胞因子释放综合症(Cytokine Release Syndrome,CRS)。 图7.细胞因子风暴的病理机制和使用托珠单抗通过IL-6阻断治疗[3] 以上,是分享给大家的关于多功能细胞因子IL-6的相关...
IL-6信号传导对于Th1细胞的产生是可有可无的,但缺乏IL-6Rα的Th1细胞在免疫应答后迅速收缩,在抗原特异性攻击后无法重新扩增, 这表明在没有IL-6信号传导的情况下记忆反应存在功能缺陷。 参考资料 Simon A Jones, Brendan J Jenkins,Recent insights into targeting the IL-6 cytokine family in inflammatory disease...
参考文献 [1] Yang YZ, Zhang YJ, Xing XY, et al. IL-6 translation is a therapeutic target of human cytokine release syndrome. J Exp Med. 2023, 220(11):e20230577.
细胞因子过度产生引起的细胞因子风暴(Cytokine Storm)就是一种有害的系统性炎症,是 CAR-T 细胞治疗恐怖的「副作用」,也是新冠肺炎重症患者的「夺命杀手」。本期给大家重点介绍的就是细胞因子家族重要成员白细胞介素-6 (Interleukin- 6),简称白介素6 (IL-6)。
3.Jones, S.A.; Jenkins, B.J. Recent Insights into Targeting the IL-6 Cytokine Family in Inflammatory Diseases and Cancer. Nat. Rev. Immunol. 2018, 18, 773–789 4.Melanie Werner-Klein et al,Interleukin-6 trans-signaling is a candidate mechanis...
3.Jones, S.A.; Jenkins, B.J. Recent Insights into Targeting the IL-6 Cytokine Family in Inflammatory Diseases and Cancer. Nat. Rev. Immunol. 2018, 18, 773–789 4.Melanie Werner-Klein et al,Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during...
细胞因子释放综合征(CRS)也被称为细胞因子风暴(Cytokine storm),是CAR-T细胞输注后最常见的毒副作用。CRS通常发生在CAR-T细胞治疗后的第一周,发生率较高,超80%的患者发生3级及以上血液学毒性和几乎100%的免疫学毒性。多发性骨髓瘤患者CAR-T细胞治疗后CRS的发生率可高达90%。
Elabscience® 白介素ELISA试剂盒涵盖目前研究热点中的多数白介素家族成员,白介素6指标是其畅销产品系列,其中大鼠白介素6指标引用文章达156篇,小鼠白介素6指标引用文章达134篇…… 参考文献: 1. Sujin Kang et al. Historical overview of the interleukin-6 family cytokine.2020. J. Exp. Med. 2020 Vol....
2.Masashi Narazaki and Tadamitsu Kishimoto, The Two-Faced Cytokine IL-6 in Host Defense and Diseases, Int. J. Mol. Sci. 2018, 19, 3528. 3.Mansur Aliyu et.al, Interleukin-6 cytokine: An overview of the immune ...