白介素-6(IL-6)是一种非冗余细胞因子,参与T辅助细胞17(TH17)细胞的分化。幼稚T细胞通过其膜结合IL-6受体(IL-6R)感知IL-6; IL-6阻止了转化生长因子-β(TGFβ)介导的FOXP3的诱导,并促进了视黄酸受体相关的孤儿核受体γ(ROR-γt)(TH17的主要转录因子)的表达细胞。然而,仅当树突状细胞(DC)将IL-6转染至T...
1. Felger, J.C., and Lotrich, F.E. (2013). Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications.Neuroscience246, 199–229. 2. Hunter, C.A., and Jones, S.A. (2015). IL-6 as a keystone cytokine in health and disease.Nat. Immunol.16, 448–457...
IL-6信号传导对于Th1细胞的产生是可有可无的,但缺乏IL-6Rα的Th1细胞在免疫应答后迅速收缩,在抗原特异性攻击后无法重新扩增, 这表明在没有IL-6信号传导的情况下记忆反应存在功能缺陷。 参考资料 Simon A Jones, Brendan J Jenkins,Recent insights into targeting the IL-6 cytokine family in inflammatory disease...
然而,这一过程也会使机体付出相应的代价,那就是IL-6水平升高会加重炎症反应的进行,这也解释了之前观测到的压力会使炎症疾病加重的现象。 原文链接: https://doi.org/10.1016/j.cell.2020.05.054 制版人:Kira 参考文献 1. Felger, J.C., and Lotrich, F.E. (2013). Inflammatory cytokines in depression:...
3.Jones, S.A.; Jenkins, B.J. Recent Insights into Targeting the IL-6 Cytokine Family in Inflammatory Diseases and Cancer. Nat. Rev. Immunol. 2018, 18, 773–789 4.Melanie Werner-Klein et al,Interleukin-6 trans-signaling is a candidate mechanis...
[8].Immunotherapeutic implications of IL-6 blockade for cytokine storm. [9].IL-6 as a keystone cytokine in health and disease. [10].Targeting interleukin-6 in inflammatory autoimmune diseases and cancers. [11].Interleukin (IL-6) Immunotherapy. ...
3.Jones, S.A.; Jenkins, B.J. Recent Insights into Targeting the IL-6 Cytokine Family in Inflammatory Diseases and Cancer. Nat. Rev. Immunol. 2018, 18, 773–789 4.Melanie Werner-Klein et al,Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during...
IL-6复溶: 1、试剂开盖前请先离心。 2、复溶浓度应大于100 μg/ml. 3、冻干蛋白溶于ddH2O中 4、复溶后根据使用量分装保存,避免反复冻融。关于IL-6: Interleukin-6 (IL-6) is a pro-inflammatory cytokine that also has an important role in immunity. Mouse IL-6 appears to be directly involved...
[18] Hui, Wang, et al. "A model of inflammatory arthritis highlights a role for oncostatin M in pro-inflammatory cytokine-induced bone destruction via RANK/ RANKL." Arthritis Res Ther 7 (2004): 1-8.[19] Le Goff, Benoit, et al. "Oncostatin M acting via OSMR, augments the actions of...
[18] Hui, Wang, et al. "A model of inflammatory arthritis highlights a role for oncostatin M in pro-inflammatory cytokine-induced bone destruction via RANK/ RANKL." Arthritis Res Ther 7 (2004): 1-8. [19] Le Goff, Benoit, et al. "Oncostatin M acting via OSMR, augments the actions ...