发现可溶性白介素2受体(solubleIL-2 receptor,sIL-2R)这个指标为 4924U/mL,随后患者出现了肝损,凝血障碍,骨髓涂片发现噬血细胞占有核细胞比例为10%,被诊断为噬血细胞综合征,病情非常凶险,不过经过积极治疗,李老伯度过了危险期。
Diagnosis of HLH can be established when five of eight criteria, one of which is elevated soluble IL2-receptor-alpha (sIL2-Ra), are fulfilled.1Mortality is high, despite HLH04 chemotherapy, prompting the search for better biomarkers of disease activity. To assess the utility of sIL2-Ra in ...
The interleukin (IL)-2 – IL-2 receptor (IL-2R) pathway is important in immunity, but is also involved in maintenance of self-tolerance. This paradox is further complicated by shedding of the IL-2Rα chain, revealing soluble (s)IL-2R. Binding of IL-2 to sIL-2R may either reduce ...
致病因素:细胞因子风暴是由不同因素导致的,常见的有先天基因突变(家族性HLH)、风湿疾病本身(SLE、sJIA、AOSD)、感染、医源性干预(如造血干细胞移植、肿瘤免疫疗法CART疗法、使用单克隆抗体类药物)等等2。不同因素导致的CRS参与的主导炎症细胞及细胞因子不一样2,即便都是由病毒感染引起的细胞因子风暴,不同病毒株引起...
产品名称:Recombinant Human IL-1 Receptor-Like 2/IL-1RL2 (C-6His) 氨基酸序列:DGCKDIFMKNEILSASQPFAFNCTFPPITSGEVSVTWYKNSSKIPVSKIIQSRIHQDETWILFLP MEWGDSGVYQCVIKGRDSCHRIHVNLTVFEKHWCDTSIGGLPNLSDEYKQILHLGKDDSLTCHLH FPKSCVLGPIKWYKDCNEIKGERFTVLETRLLVSNVSAEDRGNYACQAILTHSGKQYEVLNGITV SITERAGYGGSVPKII...
结果NKTCL病例血清IL-6显著增高,49例未合并嗜血细胞综合征(Non-HLH)患者为2.56(0~22.29)pg/ml;而10例合并HLH患者为102.11(23.44~5 871.24)pg/ml。在发热、晚期、高KPI评分、化疗耐药、高C反应蛋白的NK/TCL病例中,血清IL-6浓度增高患者的比例也显著增高。在生存方面,血清IL-6浓度≥3.12 pg/ml的NKTCL病例,其...
The interaction of IL-22 with its receptor can be inhibited by a soluble IL-22 binding protein (IL-22BP or IL-22Rα2). IL-22BP is mainly expressed in mucosal tissues and in the spleen9. The IL-22BP-producing cell type is not exactly identified even though first findings show that ...
(phototrophin)[3 4]以及可能存在但尚未被鉴定的UV-B受体(UV-Breceptor)t51等光受体,时 刻监测着其生长环境中光质、光强和光周期等条件的变化,不断调节自身的生长发育, 以最大限度适应周围环境。其中,i光敏色素对植物的影响最为明显,研究的也最为深入 ...
J13LN-scid2T line showed T-cell markers (CD5 and CD8) and an IL-2 receptor marker (CD25), but not a B-cell marker (CD79a). Detection of the EBV-Like Genome HVP-EBER-1 Expression The HVP-EBER-1-ISH revealed that most of the 594S cells expressed EBER-1. In all 17 cases (100...
26 Alternatively, the release of granulocyte macrophage colony stimulating factor (GM-CSF) by activated CAR T cells has been harnessed to achieve autocrine stimulation of a GM-CSF/IL18 receptor heterodimer pair. However, this solution does not elicit the immunomodulatory effects of IL18 on other ...