Figure 1. IL-17 signaling pathway in SPP1+ macrophages drives digestive tract cancer (DTC) progression. (A) The volcano plot of differentially expressed genes (DEGs) in DTCs. (B) Co-expression of DEGs in DTCs was detected by Venn diagram. (C) Protein–protein interaction analysis of common...
The active components of saffron can reduce the expression of inflammatory factors and ameliorate the immunological microenvironment of tumors via the IL-17 signaling pathway, thereby improving the efficacy of immunotherapy for colorectal cancer. This study provides pharmacological support for the application...
intheproliferationandmetastasisofgastriccancerandthemechanismofactioninangiogenesis,providingnewideasfortheindepthstudyoftheroleofIL17anditsrelatedsignalingpathwaysintheoccurrenceanddevelopmentofgastriccancerandtheclinicaldiagnosisandtreatmentofgastriccancer. [Keywords]gastriccancer;inflammatoryimmunity;IL17;signalingpathway...
Aberrant signaling of IL-17 implicates the pathogenesis of several autoimmune diseases, including idiopathic pulmonary fibrosis, acute lung injury, chronic airway disease, and cancer58. Literature research on the enrichment gene of the IL-17 signaling pathway in the first place showed that CCL12 ...
A novel cancer metastasis pathway That tumorigenesis can be closely linked to an inflammatory microenvironment has been well established. In a new study, Karin de Visser and colleagues estimate the more systemic inflammatory effects observed in a mouse model of breast cancer. They find that interleuki...
Wu X, Yang T, Liu X, Guo JN, Xie T, Ding Y, Lin M, Yang H. IL-17 promotes tumor angiogenesis through Stat3 pathway mediated upregulation of VEGF in gastric cancer.Tumour Biol. 2016 Apr. 37(4):5493–5501. doi:10.1007/s13277-015-4372-4. ...
Recent studies have demonstrated that the IL-17 signaling pathway not only plays a vital role in autoimmune and inflammatory diseases, but also accelerates various cancer progression [17,18,19]. Of note, various studies have shown an increased expression of IL-17 A and IL-17RA in PCa and ...
TGF-beta signaling in lung health and disease. Int J Mol Sci. 2018;19(8):2460. https://doi.org/10.3390/ijms19082460. Article CAS PubMed Central Google Scholar Kanterman J, Sade-Feldman M, Baniyash M. New insights into chronic inflammation-induced immunosuppression. Semin Cancer Biol. ...
Traditionally, the success of cancer treatment has been assessed... SI Nam,DW Song,BH Ahn,... 被引量: 4发表: 2001年 加载更多来源期刊 American journal of cancer research 2021 研究点推荐 laryngeal squamous cell carcinoma IL-17 signaling pathway 站内活动 ...
The immunosuppressive microenvironment caused by several intrinsic and extrinsic mechanism has brought great challenges to the immunotherapy of pancreatic cancer. We identified GFPT2, the key enzyme in hexosamine biosynthesis pathway (HBP), as an immune-related prognostic gene in pancreatic cancer using ...