IL-15 主要由单核细胞和巨噬细胞产生,与反应细胞上的 IL-15 受体(IL-15 receptor, IL-15R)结合,具有介导 T 细胞、NK(natural killer)细胞和 B 细胞增殖与活化,诱导细胞毒性淋巴细胞(cytotoxic T lymphocyte, CTL)产生等作用。IL-15 在抗肿瘤、自身免疫性疾病...
3.Lodolce J P, Boone D L, Chai S, et al. IL-15 Receptor Maintains Lymphoid Homeostasis by Supporting Lymphocyte Homing and Proliferation[J]. Immunity, 1998, 9(5): 669-676. 4.Kennedy, M.K., et al., Reversible defects in natural killer and ...
IL15的作用领域并不只限于免疫系统相关的疾病,在缺血性脑卒的发生过程中也扮演着重要的角色。研究发现在缺血再灌注后的星形胶质细胞中IL-15表达显着增加,施用IL15可减少AGD期间的神经元细胞死亡,这是因为IL-15可以通过缓解内质网应激和增加细胞存活来调节皮质神经元对缺血后的反应,达到挽救病人的生命的目的。 美国食...
小鼠白介素15(IL15)检测试剂盒同类产品推荐:XY-E30661 【中文名称】大鼠骨成型蛋白受体Ⅱ(BMPR-Ⅱ)ELISA试剂盒品牌 【英文名称】Rat Bone morphogenetic protein receptor Ⅱ,BMPR-Ⅱ ELISA试剂盒多少钱 XY-E30662 【中文名称】大鼠骨成型蛋白受体1A(BMPR-1A)ELISA试剂盒品牌 【英文名称】Rat Bone morphogenetic pr...
英文名称: Human interleukin 15 receptor subunit alpha ELISA Kit 用途: 预先包被的抗体和检测相抗体都是亲和纯化的IL-15Rα多克隆抗体。检测相抗体经生物素标记。样品和生物素标记抗体先后加入酶标板孔反应后,PBS或TBS洗涤。随后加入过氧化物酶标记的亲和素反应;经过PBS或TBS的彻底洗涤后用底物TMB显色。TMB在过...
4. Carson, W.E., et al., Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor.J Exp Med, 1994. 180(4): p. 1395-403. 5. Carson, W.E., et al., Endogenous production of interleukin 15 by activated human monocytes ...
分子名:IL15, interleukin 15 别称: IL-15 interleukin-15 MGC9721 基因序列:NCBI_Gene:3600 蛋白序列:UniProtKB:P40933 人Human IL15靶点分子功能(预测) Predicted to enable cytokine activity. Involved in several processes, including cell surface receptor signaling pathway; macrophage differentiation; and posi...
【3】 Zhou J, Jin L, Wang F, Zhang Y, Liu B, Zhao T. Chimeric antigen receptor T (CAR-T) cells expanded with IL-7/IL-15 mediate superior antitumor effects. Protein Cell. 2019 Oct;10(10):764-769. 关于同立海源 北京同立海源生物科技有限公司,成立十余年专注细胞和基因治疗(CGT)上游GMP...
IL-1α和IL-1βb 的生物活性由 IL-1R1(IL-1 type I receptor)介导,结合诱导 IL-1R1 胞外区构象变化,使其与 IL-1RAcP 相互作用,IL-1RAcP 是细胞内信号传导所必需的。 图片来源于文献:Structural Basis of IL-1 Family Cytokine Signaling 图1 . IL-1信号通路图 IL-10 通路 IL-10家族中有9个成员...
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits,and may compete for the same receptor,and thus neg...