However, B cells are also implicated in regulating SLE and other autoimmune syndromes via release of IL-10. B cells secreting IL-10 were termed "Bregs" and were proposed as a separate subset of cells, a concept that remains controversial. The balance between pro- and anti-inflammatory ...
IL-10-producing regulatory B cells (B10 cells) in autoimmune disease . Arthritis Res Ther 15 : S1 .Kalampokis I, Yoshizaki A, Tedder TF (2013) IL-10-producing regulatory B cells (B10 cells) in autoimmune disease. Arthritis Res Ther 15(Suppl 1):S1. : 10.1186/ar3907 Central...
Regulatory B (Breg) cells are essential to the maintenance of peripheral tolerance, but upregulated Breg response may impede the clearance of pathogens and tumor cells. Here, we found that in PBMCs, the frequency of IL-10+ circulating B cells ex vivo and following stimulation was similar ...
b, MS-determined GABA levels in B cells from LN (n = 10), spleen (SPL; n = 4), bone marrow (BM; n = 3), Peyer’s patches (PP; n = 4) and small intestinal lamina propria IgA+ plasma cells (SILP IgA+ PC; n = 4), relative to naive CD4+ T cells...
IL-10是一种多功能负性调节因子，主要由Th2细胞、活化的B细胞、单核细胞、巨噬细胞产生，它参与免疫细胞、炎症细胞、肿瘤细胞等多种细胞的生物调节，在自身免疫性疾病、严重感染性疾病、肿瘤及移植免疫等多种疾病中发挥重要作用。1.IL-10与炎症IL-10是一种抗炎性因子，发挥下调炎症反应，拮抗炎性介质...
B Thelen,V Schipperges,P Knrlein,... - 《Frontiers in Immunology》 被引量: 0发表: 2023年 IL-10-overexpressing B cells regulate innate and adaptive immune responses Background: Distinct human IL-10-producing B-cell Akdis,Cezmi,A.,... - 《Journal of Allergy & Clinical Immunology》 被引...
B cells have essential functions in multiple sclerosis and in its mouse model, experimental autoimmune encephalomyelitis, both as drivers and suppressors of the disease. The suppressive effects are driven by a regulatory B cell (Breg) population that fun
B cells and plasma cells. We show that B cell-derived GABA promotes monocyte differentiation into anti-inflammatory macrophages that secrete interleukin-10 and inhibit CD8+ T cell killer function. In mice, B cell deficiency or B cell...
大鼠缺乏产内生性IL-10的调节性B细胞加重病情,且Th1/Th17的表达增加而在调节性T细胞中减少 Source Division of Medicine, Centre for Rheumatology Research, University College London, London W1T 4JF, United Kingdom. Abstract IL-10-producing B cells, also known asregulatoryB cells (Bregs), play a ke...
Non-specific immune responses to antigens have been demonstrated as being enhanced during chronic hepatitis B virus (HBV) infection. Here, we evaluated the role of interleukin-10 (IL-10)-producing regulatory B-cells (Bregs) in the pathogenesis of HBV-related liver fibrosis (HBV-LF) and assess...