⼤多数⽩细胞介素的免疫功能在某种程度上是已知的。Abbkine带⼤家了解IL-1、IL-4、IL-6和IL- 33的受体、细胞靶点和主要功能。IL-1（IL-1 alpha、IL-1 beta）⼏乎影响所有细胞和器官，并且是⾃⾝炎症、⾃⾝免疫、感染性和退⾏性疾病的主要致病介 质。受体：CD121a/IL1R1, CD121b/IL1R2 ...
Alpha多样性分析 .02 由图4可知,M组Chao1指数和Observed species指数最低,PCa组Chao1指数和Observed species指数显著高于M组(P<0.05),这表明卵巢切除小鼠肠道菌群丰富度降低,补充CP使OP小鼠肠道群落丰富度增加。Shannon指数和Simpson指数能...
IL-1(IL-1 alpha、IL-1 beta) 几乎影响所有细胞和器官,并且是自身炎症、自身免疫、感染性和退行性疾病的主要致病介质。 CD121a/IL1R1, CD121b/IL1R2 CD4+细胞 共刺激 B细胞 成熟&增殖 NK细胞 活化 巨噬细胞、内皮细胞、其他细胞 参与炎症反应,少量引起急性期反应,大量引起发热 IL-4 除了在介导炎症性过...
IL-1由IL-1α和IL-1β组成,它们是不同基因的产物,但被两种不同的IL-1受体识别。IL-1受体I型,一种80kDa的跨膜蛋白,具有IL-1信号传导功能;IL-1受II型,一种68kDa的膜蛋白,具有相对较短的细胞质尾II型受体作为IL-1的诱饵靶,通过阻止IL-1...
mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can...
transduction. IL-1 RII has high affinity for IL-1 beta but functions as a decoy receptor and negative regulator of IL-1 beta activity. IL-1ra functions as a competitive antagonist by preventing IL-1 alpha and IL-1 beta from interacting with IL-1 RI. The porcine IL-1 beta cDNA encodes...
Interleukin-1 beta (IL-1β) is a pro inflammatory cytokine, which is secreted by immune cells to trigger inflammation and this has been found profoundly in the lesions caused by Leishmania pathogens. IL-1 is a name that designates two pleiotropic cytokines, IL-1 alpha (IL-1F1) and IL-1...
IL-1B质量控制:>95%(SEC-HPLC,还原性SDS-PAGE)IL-1B制剂:冻干品IL-1B保存:关于IL-1B:IL1B is a 269 amino acids protein which belongs to the IL-1 family. Interleukin 1 (IL-1) is a family of polypeptide cytokines consisting of two agonists, IL-1 alpha (IL-1F1) and IL-1 beta (...
stimulatory effect of IL1-beta on the production of soluble and intracellular forms of IL-1RN. The regulated expression of IL-1RN in various cell types has been shown to be influenced by cytokines. In synovial fibroblasts, IL-1, TNF-alpha, or PDGF markedly enhances the synthesis of IL-1...