The IkappaB kinase complex in NF-kappaB regula- tion and beyond. EMBO Rep. 15, 46-61.Hinz M,Scheidereit C.The Ikappa B kinase complex in NFkappa B regulation and beyond[J].EMBO Reports,2014,15(1):46-61.M. Hinz, C. Scheidereit, The IkappaB kinase complex in NF-kappaB regulation...
The IkappaB kinase (IKK) complex is composed of three subunits, IKKalpha, IKKbeta, and IKKgamma (NEMO). While IKKalpha and IKKbeta are highly similar catalytic subunits, both capable of IkappaB phosphorylation in vitro, IKKgamma is a regulatory subunit. Previous biochemical and genetic analyses...
I kappa B kinase (IKK) complex, the master kinase for NF-kappa B activation, contains two kinase subunits, IKK alpha and IKK beta. In addition to mediating NF-kappa B signaling by phosphorylating I kappa B proteins during inflammatory and immune responses, the activation of the IKK complex ...
The I[kappa]B kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1 Toll-like receptor () signaling activates the inhibitor of factor NF-κB (IκB) kinase (IKK) complex, which governs NF-κB-mediated during inflammation. ...
The IkappaB kinase (IKK) complex is a central component in the classic activation of the nuclear factor-kappaB (NF-kappaB) pathway. It has been reported to function in physiologic responses, including cell death and inflammation. We have shown that IKK is regulated by oxidative status after tra...
Tumor Necrosis Factor Receptor-associated Factor-6 and Ribosomal S6 Kinase Intracellular Pathways Link the Angiotensin II AT1 Receptor to the Phosphorylation and Activation of the I B Kinase Complex in Vascular Smooth Muscle Cells Servant, Tumor necrosis factor receptor-associated factor-6 and ribosomal...
Activation of the transcription factor nuclear factor kappa B (NF-kappaB) is controlled by sequential phosphorylation, ubiquitination, and degradation of its inhibitory subunit IkappaB. A large multiprotein complex, the IkappaB kinase (IKK) signalsome, was purified from HeLa cells and found to conta...
S2882IKK-16IKK-16 is a selective IκB kinase (IKK) inhibitor forIKK-2,IKK complexandIKK-1withIC50of 40 nM, 70 nM and 200 nM in cell-free assays, respectively. IKK-16 also inhibits LRRK2 Ser935 phosphorylation in cells and LRRK2 kinase activity in vitro with IC50 of 50 nM. ...
Taken together, our results suggest that PKC acts upstream of PKC to activate the IKK complex and NF- B in T lymphocytes following TCR activationTrushinPenningtonCarmonaTrushin S A,Pennington K N, et al.Protein kinase C alpha (PKCalpha) acts upstream of PKC theta to...
IKK complex includes two catalytic components, IKKα and IKKβ. As a downstream target, Aur-A was phosphorylated by IKKα at threonine residue 288, a site which is important for its kinase activity [26]. Depletion of IKKβ resulted in the up-regulation of Aur-A protein, and IKKβ ...