2:Regnier CH, Song HY, Gao X, et al. Identification and characterization of an IkappaB kinase. Cell 1997; 90:373-83.3:Zandi E, Rothwarf DM, Delhase M, et al. The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation...
IKK-alpha (IKK-α) and IKK-beta (IKK-β) Two distinct approaches, one relying onprotein purificationand the other on yeast two-hybrid screening, have identified the same two relatedpolypeptides, termed IKK-α or IKK-1 and IKK-β or IKK-2, as having the requisite IkB-specific ki...
I-kappa-B-beta I-kappa-B-kinase beta I-KappaB-Associated Protein I-language I-language I-LCT I-LEAD I-LEVEL I-Link I-LOP I-mac I-mac I-MARC I-MARK I-MASF I-max I-max I-MCFSA I-MILES I-MIMO I-MOD I-mode I-mode I-mode I-MTS I-MUX I-name i-name service I-names I-...
IP results from mutations in the inhibitor of kappa beta kinase gamma (IKBKG, 300248), formerly known as NEMO, located on locus Xq28.46 IKBKG mutations are found in approximately 70% of individuals with IP. In 60–88% of IP patients harboring a mutation, a common deletion of...
4.2. IKKβ (Inhibitor of κB Kinase Beta) In contrast to IKKα, IKKβ is predominantly associated with the canonical NF-κB pathway. One of its key functions is the phosphorylation of IκBα and IκBβ. This phosphorylation event marks IκB proteins for degradation, allowing the release of...
The Gefitinib+IKK16 combination further inhibited the phosphorylation of the mammalian target of rapamycin (mTOR), glycogen synthase kinase-3 beta (GSK3β), and ribosomal protein S6 (RPS6) compared with the single treatments. Phosphorylation and nuclear translocation of NF-κB p65 was further ...
Our results suggest that Cys-179 of IKKbeta plays a critical role in enzyme activation by promoting phosphorylation of activation-loop serines and interaction with ATP. 展开 关键词: cysteine IκB kinase NF-κB phosphorylation protein serine-threonine kinases ...
PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling. NF-kappa B signaling is required for the maintenance of normal B lymphocytes, whereas dysregulated NF-kappa B activation contributes to B cell lymphomas. T... TT Su,B Guo,Y Kawakami,... ...
英文名称:IKKB phosphorylated Inhibitor Of Nuclear Factor kappa B Kinase beta Subunit I kappa B kinase beta IkBKB B kappa Kinase 2 Nuclear Factor NF Inhibitor IKKBIKKB phosphorylated Inhibitor Of Nuclear Factor,中文名称:核因子kappa B激酶β亚基磷酸化抑制
4:Woronicz JD, Gao X, Cao Z, et al. IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK. Science 1997; 278:866-9. 艾美捷ProSci该套装化学性质: 目录号:PSI-1821 克隆性:多克隆 测试应用:ICC、IF、IHC、WB ...