IgD+ IgM- B cells mount immune responses that exhibit altered antibody repertoire. Eur J Immunol 2004; 34:661-8.Han S, Zhang X, Xu R, Finkelman FD, Brombacher F, Zheng B. IgD+IgM- B cells mount immune responses that exhibit altered antibody repertoire. Eur J Immunol. 2004; 34 :661...
(1993) Human IgM+ IgD+ B cells, the major B cell subset in the peripheral blood, express VK genes with no or little somatic mutation throughout life. Eur. J. Im- munol. 23: 3272-3277.Klein, U, Kuppers, R, Rajewsky, K.Human IgM+IgD+ B cells, the major B cell subset in the ...
IgD+IgM- B cells mount immune responses that exhibit altered antibody repertoire Han S, Zhang X, Xu R, Finkelman FD, Brombacher F, Zheng B. IgD+IgM- B cells mount immune responses that exhibit altered antibody repertoire. Eur J... S Han,X Zhang,R Xu,... - 《European Journal of ...
IL-10+ B cells are critical for immune homeostasis and restraining immune responses in infection, cancer, and inflammation; however, the signals that govern IL-10+ B cell differentiation are ill-defined. Here we find that IL-10+ B cells expand in mice la
The lack of memory B cells including T cell independent IgM+ IgD+ memory B cells in chronic graft-versus host disease is associated with susceptibility ... Hilgendorf,I.,Mueller-Hilke,... - 《Transplant International Official Journal of the European Society for Organ Transplantation》 被引量: ...
The ontogeny of serum IgG, IgA, IgM and IgD in 312 members of a southern United States population was studied. Circulating IgD was found in all adolescents and in 97% of the adults tested. IgD levels increased until adult life. Females had statistically significantly higher levels of Igtd th...
Naive B cells initially co-express BCRs of the IgM and IgD classes. Unlike IgM and IgG, IgD is expressed almost exclusively as a BCR rather than secreted antibody and possesses a characteristic, elongated hinge domain (White et al., 1985). Activation by foreign antigen and cognate CD4+ T ...
(see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD (see...
Flow cytometric analysis of peripheral blood lymphocytes revealed a reduction of class-switched CD27(+)IgM(-)IgD(-) memory B cells below 0.4% in 77% of our patients (group I), while this B-cell subpopulation exceeded 0.5% in all healthy donors and in 23% of CVID patients (group II)....
THE antigen receptors on mature B lymphocytes are membrane-bound immunoglobulins of the IgM and IgD classes 1,2 whose cross-linking by polyvalent antigens results in B-cell proliferation and differentiation 3 . How these membrane-bound immunoglobulin chains, which lack a cytoplasmic tail, generate ...