IgG4-related disease (IgG4-RD) is a systemic, immune-mediated fibroinflammatory condition capable of affecting multiple organs.IgG4相关疾病是一种系统性、免疫介导的纤维炎症性疾病,可累及多个器官。 Key Features (主要特点): Pathology (病理特点):Lymphoplasmacytic infiltrates, storiform fibrosis, and ...
IgG4-related disease(IgG4-RD)is a newly recognized systemic fibro-inflammatory condition and had been named in 2010.It has aroused wide interest from researchers all over the world.IgG4-RD,the cause of which is still unclear,is a unknowned chronic progressive autoimmune disease.A wide range o...
IgG4-related disease (IgG4-RD) is a systemic inflammatory disease characterized by IgG4-positive plasma cell and T lymphocyte infiltration of multiple organs. It commonly involves the pancreas, lacrimal glands, and salivary glands, and it has been rarely reported in the sinonasal...
[54]Stagner AM . Histopathologic clues to the etiopathogenesis of orbital inflammatory disease: Idiopathic, IgG4-related, neoplastic, autoimmune and beyond[J]. Semin Diagn Pathol, 2024,41(2):66-71. DOI: 10.1053/j.semdp.2024.01.011 . ...
(IgG4-related disease,IgG4-RD);唾液腺(salivary gland);Mikulicz病(Mikulicz disease);Küttner瘤(Küttner tumor);腮腺(parotid gland);下颌下腺(submandibular gland);泪腺(lacrimal gland);眼眶(orbital);鼻旁窦(paranasal sinuses);鼻腔...
此外,IgG4相关疾病,immunoglobulin G4-related disease, IgG4-RD,是一种免疫介导的纤维炎性疾病,也可累及多个器官,部分类型与自身免疫性疾病有重叠。 IgG4相关疾病 IgG4-RD表现为看似无关的多器官受累(可累及一个或多个器官,几乎每个器官系统都发现过),从早期的增殖性和炎症性阶段(治疗通常有效)进展至纤维化...
IgG4相关眼病(immunoglobulin-G4 related ophthalmic disease,IgG4-ROD)是一种眼部由免疫介导的慢性炎症伴纤维化性的疾病,主要组织病理表现为IgG4 +浆细胞浸润,并伴有席纹状纤维化、闭塞性静脉炎和嗜酸性粒细胞浸润。显著升高的血清IgG4水平和肿块样病变是该病最常见的临床表现 [ 1 ] 。IgG4-ROD可累及多种眼部组...
Immunoglobulin G4-related disease (IgG4-RD) is a systemic inflammatory disease characterized by chronic activation of the immune system with subsequent tissue fibrosis. It can affect a wide variety of different organ systems. The most common form of renal involvement (IgG4-RKD) is tubulointerstitial...
IgG4-related disease (IgG4-RD) represents an immune-mediated fibroinflammatory condition with peculiar histopathologic changes that can affect various organs. In 2012 its unified nomenclature was published, which allows to abandon other synonymous names. Up to now, only little is known about its epi...
Immunoglobulin G4- related disease (IgG4-RD) is a rare systemic fibro-inflammatory disorder (ORPHA284264). Although patients have been described more than 100 years ago, the systemic nature of this disease has been recognized in the 21st century onl