Showed an invasive pattern with destruction of adipo-cytes, dense sclerosis with patchy chronic inflammation, and focal obliterative phlebitis. IgG4 cell numbers were 128 per high power field (hpf) and IgG4/IgG ratio was 60% (threshold: 50 cells per hpf and ratio over 40%2). A diagnosis ...
2007年Bjornsso等建议使用IgG4相关性胆管炎(immunoglobulin G4 associated cholangitis,IAC)这一名称。IAC的生化和胆道造影表现与原发性硬化性胆管炎(primary sclerosis cholangitis,PSC)相似,常累及肝外胆管。血清IgG4水平升高、胆管与肝组织中大量IgG4阳性浆细胞浸润是其特征性表现,激素治疗对IAC有效。IAC常伴有AIP,但...
2007年Bjornsso等建议使用IgG4相关性胆管炎(immunoglobulin G4 associated cholangitis,IAC)这一名称。IAC的生化和胆道造影表现与原发性硬化性胆管炎(primary sclerosis cholangitis,PSC)相似,常累及肝外胆管。血清IgG4水平升高、胆管与肝组织中大量IgG4阳性浆细胞浸润是其特征性表现,激素治疗对IAC有效。IAC常伴有AIP,但...
3. Dahlgren M, Khosroshahi A, Nielsen GP, et al: Riedel's thyroiditis and multifocal fibrosclerosis are part of the IgG4-related systemic disease spectrum.Arthritis Care Res (Hoboken)2010,62:1312-1318. 4. Saeki T, Saito A, Hiura T, et al: Lymphoplasmacytic infiltration of multiple organ...
IgG4相关性疾病有许多曾用名,如:米库利兹病( Mikulicz disease)、Küttner 瘤( Küttner tumor)、Riedel 甲状腺炎( Riedel thyroiditis)、多灶性纤维硬化( Multifocal fibrosclerosis)等等。 IgG4相关性疾病可累及全身多脏器/解剖部位,对不同脏器/部位的受累,存在对应的...
[2] Sarles H, Sarles J C, Muratore R, et al. Chronic inflammatory sclerosis of the pancreas--an autonomous pancreatic disease?[J]. Am J Dig Dis, 1961, 6: 688-698. [3] Kawaguchi K, Koike M, Tsuruta K, et al. Lymphoplasmacytic sclerosing pancreatitis with cholangitis: a variant of...
lungs) [50,64,65,66,67,68] and/or pancreatobiliary [7,69] fibroinflammatory lesions. Bateman et al. [59] have also reported venous damage, which leads to phlebitis obliterans as seen in IgG4-RSD. Such systemic clinical settings are conveniently known as multifocal systemic sclerosis [50,70...
IgG4相关性疾病有许多曾用名,如:米库利兹病( Mikulicz disease)、Küttner 瘤( Küttner tumor)、Riedel 甲状腺炎( Riedel thyroiditis)、多灶性纤维硬化( Multifocal fibrosclerosis)等等。 IgG4相关性疾病可累及全身多脏器/解剖部位,对不同脏器/部位的受累,存在对应的命名:IgG4相关性胰腺炎、IgG4相关性泪腺炎、IgG...
比如natalizumab (Tysabri®),它是鼠源单克隆抗体通过互补决定区人源化嫁接入人IgG4框架的一种重组IgG4抗体,可中和α4-整合素 (α4-integrin) 用于治疗多发性硬化 (multiple sclerosis,MS)。Natalizumab选择性抑制α4-整合素介导的淋巴细胞对内皮受体的黏附 (血管细胞黏附分子1和黏膜地址素细胞黏附分子1),从而阻止...
炎性肌病 • Systematic Sclerosis 系统性硬化症 • Systemic Vasculitis 系统性血管炎 Rheumatology & Autoimmunity竭诚欢迎风湿病与免疫学领域的科研工作者、医生、研究生积极向期刊投稿。 期刊主页: https://onlinelibrary.wiley.com/journa...