Results of FISH showed that IGF2BP2‐AS1 was mainly present in the cytoplasm. Further in vitro functional tests demonstrated that downregulation of IGF2BP2‐AS1 in Cal27 and SCC9 cells significantly inhibited cell proliferation and migration, leading to cell‐cycle arrest and cell apoptosis. ...
IGF2BP2 promotes the progression of hepatocellular carcinoma and has a great prognostic value in hepatocellular carcinoma. • IGF2BP2 regulates the expression of lncRNA TRPC7-AS1 in hepatocellular carcinoma. • LncRNA TRPC7-AS1 could be considered as an oncogene in hepatocellular carcinoma. ...
Thus, we conclude that the stabilization of CDKN2B-AS1 by IGF2BP3 drives the malignancy of KIRC through epigenetically activating NUF2 transcription and that the IGF2BP3/CDKN2B-AS1/NUF2 axis may be an ideal prognostic and diagnostic biomarker and therapeutic target for KIRC....
reverses the radioresistance.#RBM15 induces CBR3-AS1 via an m6A-IGF2BP3 mechanism, promoting NSCLC radioresistance.#CBR3-AS1 induces CXCL1 by sponging miR-409-3p to recruit MDSCs and inhibit T cells.#RBM15 is a radiosensitization target for NSCLC as the RBM15 depletion reverses the ...
A1BG-AS1 knockdown enhanced the ADR sensitivity by suppressing the viability, proliferation potential and migration ability, and facilitating cell apoptosis in BC. Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) is known to be an m6A reader to modulate ...
Furthermore, RNA pull-down, mass spectrometry, RNA immunoprecipitation, and rescue analyses revealed that BMPR1B-AS1 positively regulates decidual formation through interaction with the RNA-binding protein insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2). Downregulat...
RHPN1-AS1miR-596IGF2BP2HCConcogenic lncRNACCK-8Background: Hepatocellular carcinoma (HCC) is one of the most deadly cancer types worldwide, and its incidence is high in China. Multiple long non-coding RNAs (lncRNAs) have been recently identified as crucial oncogenic factors or tumor ...
RHPN1-AS1 Drives the Progression of Hepatocellular Carcinoma via Regulating miR-596/IGF2BP2 Axisdoi:info:doi/10.2174/1381612825666191105104549Fen, HuHongmin, ZhengWei, WeiChao, YangYang, YaoBei, LiuZhihua, SunCurrent Pharmaceutical Design
In summary, our research identified the MSC-AS1/miR-302a-3p/IGF2BP2/LEF1 axis in melanoma development, which indicated that MSC-AS1 is a potential biomarker in the treatment of melanoma.doi:10.1111/exd.14427Yan MaDepartment of Burn and Plastic Surgery Chengdu Second People’s Hospital Chengdu...
Thus, we conclude that the stabilization of CDKN2B-AS1 by IGF2BP3 drives the malignancy of KIRC through epigenetically activating NUF2 transcription and that the IGF2BP3/CDKN2B-AS1/NUF2 axis may be an ideal prognostic and diagnostic biomarker and therapeutic target for KIRC....