IGF-binding proteins in human prostate tumor cells: expression and regula- tion by 1,25-dihydroxyvitamin. Prostate 1995;26:72-9.Drivdahl RH, Loop SM, Andress DL, Ostenson RC. IGF-binding proteins in human prostate tumor cells: expression and regulation by 1,25-dihydroxyvitamin D3. Prostate....
背景说明:Insulin-like growth factors (IGFs) comprise a family of endocrine, paracrine and autocrine polypeptides consisting of the ligands IGF1 and IGF2, two receptors (IGF1R, IGF2R), at least 6 IGF-binding proteins (IGFBPs) and IGFBP proteases. Among the binding proteins, IGFBP6 is unique...
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The insulin-like growth factor (IGF) axis encompasses the growth factors IGF-1 and IGF-2, the type 1 and 2 IGF receptors (IGF1R and IGF2R), and a group of six binding proteins (IGFBP-1 to -6) with high affinity for IGF-1 and IGF-2. These proteins initiate, or occupy a critical...
Insulin-like growth factor-binding proteins (IGFBPS) and their regulatory dynamics The IGFBPs are a family of homologous proteins that have co-evolved with the IGFs and that confer upon the IGF regulatory system both functional and tissue... KM Kelley,Y Oh,SE Gargosky,... - 《Int J Bioch...
IGF-I and IGF Binding Proteins: Basic Research and Clinical Management N Wilczak,D Keyser 被引量: 0发表: 2005年 A meta-analysis of the effect of lowering serum levels of GH and IGF-I on mortality in acromegaly OBJECTIVE: Formal studies of acromegaly have found increased mortality associated ...
Oestradiol is important in the growth of uterine leiomyomata and may act primarily or secondarily through mediators such as growth factors, including the insulin-like growth factors (IGF-I and IGF-II), mitogenic peptides. IGF binding prote...
IGFs AND IGF BINDING PROTEINS IN HUMAN CORD SERA: RELATIONSHIP TO INTRAUTEINE GROWTHPediatric Research publishes original papers, invited reviews, and commentaries on the etiologies of diseases of children and disorders of development, extending from molecular biology to epidemiology. Use of model ...
We have previously identified insulin-like growth factor 2 (IGF2) and insulin-like growth factor 1 receptor (IGF1R) as essential proteins for tip cell maintenance and sprouting angiogenesis. In this study, we aim to identify other IGF family members involved in endothelial sprouting angiogenesis. ...
The mitogenic and metabolic effects of insulin-like growth factor-II (IGF-II) can be modulated by six distinct IGF binding proteins (IGFBPs). As a first step toward understanding the role of IGFs and their binding proteins in intestinal epithelial cell differentiation, the expression of IGF-II...