IGF-1、IGFBP-3和IGF-1/IGFBP-3摩尔比值三项结果均正常,对非GHD的矮身材诊断特异性最高为100%,这意味着矮身材患儿三项指标均正常,可基本排除GHD的可能性。单指标IGF-1水平正常对非GHD导致的矮身材,其诊断敏感性最高(90.1%)。 正常水平IGF-1...
IGF1浓度是监测生长激素(GH)治疗效果最广泛使用的参数,然而,GH疗效变化多是由血清IGF1和IGFBP3浓度的变化引起的,血清中的IGF1与IGFBP3浓度相互影响,GH治疗可能存在的不良反应与两者的浓度比值呈U形关系曲线。IGF1/IGFBP3的比值作为评估GH治疗效果和...
[2] Friedrich N, Wolthers OD, Arafat AM, et al. Age- and sex-specific reference intervals across life span for insulin-like growth factor binding protein 3 (IGFBP-3) and the IGF-I to IGFBP-3 ratio measured by new automated chemiluminescence assays. J Clin Endocrinol Metab. 2014;99(5):...
Insulin-like growth factor (IGF) binding protein-3 (IGFBP-3) is known to block IGF action and inhibit cell growth. IGFBP-3 is thought to act by sequestering free IGFs or, possibly, act via a novel IGF-independent mechanism. Supporting its role as a primary growth inhibitor, IGFBP-3 ...
[24] Juul A, Dalgaard P, Blum WF, et al. Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children, and adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation. J Clin End...
重组人胰岛素样生长因子结合蛋白-3蛋白产品,又称Insulin-like Growth Factor-Binding Protein 3, Growth-hormone-dependant binding protein.其对应NCBI基因号为3484,NCBI基因别称为IBP1;该基因种属来源为人源,对应Accession号为P08833.该蛋白产品又称Human IGF-BP3, IGF-BP3, IGFBP3, h-IGF-BP3, rh-IGF-BP3,...
重组人胰岛素样生长因子结合蛋白-3蛋白产品,又称Insulin-like Growth Factor-Binding Protein 3, Growth-hormone-dependant binding protein.其对应NCBI基因号为3486,NCBI基因别称为IBP3;该基因种属来源为人源,对应Accession号为P17936.该蛋白产品又称Human IGF-BP3, IGF-BP3, IGFBP3, h-IGF-BP3, rh-IGF-BP3,...
We studied serum IGF-1 and IGF-bindinq protein-3 (IGFBP-3) levels (RIA) in 18 ESRD P on dialysis 8.0-29.5 years old (x:18.7), and in 19 TX P 4.7-21.8 years old (x:12.9). ESRD P had lower mean IGF-1 levels (x±sd:0.66+0.25 U/ml) than TX P (1.77±0.89 U/ml, p < ...
Synonyms acid stable subunit of the 140 K IGF complex; binding protein 29; binding protein 53; growth hormone-dependent binding protein; IBP-3; IBP3BP-53; IGF-binding protein 3; IGFBP-3; insulin-like growth factor binding protein 3; insulin-like growth factor-binding protein 3 ...
胰岛素样生长因子结合蛋白-3(Insulin-like growth factor binding protein-3,IGFBP-3)是一种大分子蛋白,由多种细胞合成和分泌,是血液中IGF-1的主要载体,循环中约80%的IGF-1与IGFBP-3结合,其余IGF-1和其他的结合蛋白结合,只有1%的IGF-1为游离状态。当IGF-1和IGFBP-...