doi:10.1038/ncpendmet0799NoneNature Clinical Practice Endocrinology & 38 Metabolism
The aim of the present study was to investigate the effect of low-normal and high-normal levels of IGF-1 in growth hormone (GH) deficient adults on cognition and wellbeing during GH treatment. A randomized, open-label, clinical trial including 32 subjects receiving GH therapy for at least ...
on a grain ration and a high-fat ration. Five rats of each sex were killed at weaning... R Schemmel,O Mickelsen,U Mostosky - 《Anatomical Record》 被引量: 47发表: 1970年 Finishing season and feeding resources influence the quality of products from extensive-system Gascon pigs Part 1: ...
Linkage disequilibrium is high among the H19 SNPs (DЈ Ն0.97; R2 ϭ 0.20 – 0.72) but low between the H19 and IGF2 SNPs (DЈ Յ0.27; R2 ϭ 0). Maternal genotypes of rs4929984 sig- nificantly (p ϭ 0.04) associated with birth weight, but neither paternal nor newborn...
High insulin/IGF is a biologic link between diabetes and cancers, but the underlying molecular mechanism remains unclear. Here we report a previously unrecognized tumour-promoting mechanism for stress protein TRB3, which mediates a reciprocal antagonism between autophagic and proteasomal degradation systems...
Girls with low birth weight (LBW) and with a history of precocious pubarche in childhood (PP) are at high risk of polycystic ovary syndrome (PCOS) in adole... L Ibá?Ez,A Ferrer,K Ong,... - 《J Pediatr》 被引量: 390发表: 2004年 Precocious pubarche is associated with SGA, prematuri...
The insulin-like growth factors (IGFs) I and II exert pleiotropic effects on diverse cell types through interaction with specific high affinity cell surfac... SE Tollefsen,R Lajara,RH Mccusker,... - 《Journal of Biological Chemistry》 被引量: 520发表: 1989年 Osteogenic protein-1 regulates...
为了探究CD11c+小胶质细胞通过何种分子发挥作用,研究人员对PNI后脊髓中的CD11chigh和CD11cneg小胶质细胞进行了RNA测序,结果表明CD11chigh中的Igf1表达量显著高于CD11cneg。 利用Itgax-Cre;Igf1flox/flox小鼠特异性去除CD11c+小胶质细胞、利用Cx3cr1CreERT2;Igf1flox/flox小鼠特异性敲除小胶质细胞中的Igf1、或在野生型...
The IGF2 DMR2 exhibited a very specific methylation pattern with a high methylation level for all CpGs except CpG 7 and 9, which had methylation levels of 58 and 62%, respectively. A similar decrease of these two CpGs has been observed in other human tissues (Jammes H, unpublished) and ...
Ujihara M, Hamanaka S, Tominaga T, Gondo T. Hyper-IgE multicentric Castleman s disease: eosinophilic skin eruption, generalised lymphadenopathy, and polyclonal hyperimmunoglobulinaemia with an extremely high serum IgE level. Br J Dermatol 1996; 135:330-45....