Notably, the proportion of CD38+IgD+ was significantly and positively correlated with the serum IgG level among pSS patients (R2=0.5723). These results raise the possibility that increased serum IgG level in pSS patients was attributed to an increase in the population of this activated B cell ...
骨髓活检示:浆样细胞数量增加(约70%),Kappa阳性,Lambda阴性,CD20阴性,CD38和CD138阳性,考虑浆样细胞增生性肿瘤,不能排除浆样细胞白血病的可能,请结合临床及遗传学检查。 免疫组化:MPO、CD15粒系(+),E-cad红系(+),CD42b巨核系(+)、CD3(T细胞+)、CD20(个别...
We have identified and isolated a subpopulation of IgD+ B cells (IgD+CD38+ B cells) from human tonsils which expresses the germinal center (GC)-associated surface markers CD10, CD38, CD75, CD77 and Cd95/Fas. The heterogeneity of expression of several markers on IgD+ CD38+ B cells sugges...
Local class-switch recombination has been intimated but B cell precursors and mechanisms remain elusive. Here we describe the dynamics underlying the generation of IgE-antibody secreting cells (ASC) in human nasal polyps (NP), mucosal tissues rich in ASC without germinal centers (GC). Using VH ...
Relationship between the frequency of HIV-specific CD8+ T cells and the level of CD38+CD8+ T cells in untreated HIV-infected individuals CD8+T cells are critical for effective host defenses against viral infections. Studies addressing HIV-induced immune responses in infected individuals have... TW...
(d) Number of donor B cells in the spleen on day 2.5. (e) Number of Fas þ CD38 À CD45.1 þ B220 þ HEL-binding GC B cells in the spleen 5 days after transfer and immunization, using the gating strategy in Supplementary Figs 4–6. There was no significant difference between...
Plasmodium falciparum infection leads to alterations in B cell subset distribution. During infancy, development of peripheral B cell subsets is also occurring. However, it is unknown if infants living a malaria endemic region have alterations in B cell s
Absolute CD19+ B cell counts, including counts of immature (CD10+ CD38++ CD20+ IgM++) and transitional (CD10− CD38++ CD20+ IgM++) as well as class switched memory (CD19+ CD27+ IgM− IgD−) B cells in patients with active cGVHD (n = 52) were significantly decreased as ...
B cellGerminal centerIgDWe have identified and isolated a subpopulation of IgD+ B cells (IgD+CD38+ B cells) from human tonsils which expresses the germinal center (GC)-associated surface markers CD10, CD38, CD75, CD77 and Cd95/Fas. The heterogeneity of expression of several markers on IgD...
抗免疫球蛋白D抗体(anti-immunoglobulin D antibody,抗IgD抗体)一直以来主要作为工具药来研究正常B细胞上的膜结合型IgD(membrane IgD,m IgD).最新研究表明,在病理状态下,抗IgD抗体可以通过选择性清除成熟B细胞,降低自身抗体的水平,抑制B细胞上B细胞活化因子(B cell activating factor belonging to the TNF family,BAF...