Double negative (IgG + IgD-CD27-) B cells are increased in a cohort of moderate-severe Alzheimer's disease patients and show a pro-inflammatory ... M Bulati,S Buffa,A Martorana,... - 《Journal of Alzhmers Disease Jad》 被引量: 0发表: 2015年 B-cell phenotype and IgD-CD27- memory...
We examined the alterations of memory CD4 + T cell subsets bearing surface receptors linked to either Th1 or Th2 cytokine production as well as natural kil... X Wu,M Osoegawa,K Yamasaki,... - 《Journal of the Neurological Sciences》 被引量: 85发表: 2000年 CD5+ B cells and CD48 T...
Immunosenescence, i.e. the aging-associated decline of the capacity of the immune system, is characterized by several distinct changes in the number and functions of the immune cells. In the case of B cells, the total number of CD19+ B cells is lower in
Marginal zone B cells in infants express the enzyme activation induced deaminase (AID) essential for somatic hypermutation but in adults, these same cell types do not express AID [4]. The peripheral equivalent of the marginal zone cell is the IgM+IgD+CD27+CD19+ non-class switched memory B ...
18, 19, 20 Interestingly, such IgM+IgD+CD27+ memory B cells are also present in the blood and spleen of healthy individuals21,22 but, like the naive cell fraction, they are reportedly not a reservoir for EBV persistence.3 Here we focus on one such immune deficiency characterized by ...
Flow cytometric analysis of peripheral blood lymphocytes revealed a reduction of class-switched CD27(+)IgM(-)IgD(-) memory B cells below 0.4% in 77% of our patients (group I), while this B-cell subpopulation exceeded 0.5% in all healthy donors and in 23% of CVID patients (group II)....
We studied the distribution of peripheral B-cell subsets in patients deficient for key factors of the TLR-signaling path ways (MyD88, TIRAP/MAL, IL-1 receptor associated kinase 4 [IRAK-4], TLR3, UNC 93B, TRIF). All TLRs, except TLR3, which signals through the TRIF adaptor, require My...
浆细胞白血病(plasmacell leukemia,PCL)是一种罕见、高度侵袭的恶性浆细胞肿瘤,国外文献报道的发病率约为0.04/10万,mOS仅为4-12个月,分为原发性浆细胞白血病(pPCL)和继发性浆细胞白血病(sPCL)。pPCL发生于无多发性骨髓瘤(multiplemyeloma,MM)病史的患者,起病时外周...
[ 17 ]. the population of igd + b cells increases with disease progression that conduces to il-10 release and an increase of the inhibitory receptor pd-1, leading to t cell function suppression and to cellular exhaustion. furthermore, these cells induce other b and t lymphocytes to produce...
Alexa Fluor® 700 anti-mouse IgD Antibody - Surface IgD is an important B cell differentiation marker..