37. Tamouza H, Chemouny JM, Raskova Kafkova L, et al. The IgA1 immune complex-mediated activation of the MAPK/ERK kinase pathway in mesangial cells is associated with glomerular damage in IgA nephropathy[J]. Kidney Int, 2012, 82(12): 1284-1296. DOI:10.1038/ki.2012.192. 38. Jhee JH...
& Monteiro, R.C. Role of IgA receptors in the pathogenesis of IgA nephropathy. J. Nephrol. 29, 5-11 (2016).Lechner SM, Papista C, Chemouny JM et al. Role of IgA receptors in the pathogenesis of IgA nephropathy. J Nephrol 2016; 29 (1): 5-11....
Conclusions Among patients with IgA nephropathy and proteinuria greater than 1 g/d, oral methylprednisolone was associated with an increased risk of serious adverse events, primarily infections. Although the results are consistent with potential benefit, definitive conclusions about treatment benefit cannot ...
硕士学位论文 中文摘要 中文摘要 目的IgA肾病是当今世界上最常见的原发性肾小球疾病。大量临 床研究表明肾小管间质损害与IgA肾病的预后有密切关系.本研究通过 复制Ig A肾病大鼠模型,观察黄芪对IgA肾病大鼠肾小管间质损害的影 响;观察黄芪对实验性IgA肾病大鼠尿蛋白、尿NAG酶、肾脏病理以及 肾组织核转录因子-rmp65...
IgA nephropathy is a common glomerulonephritis consequent to the autoimmune response to aberrant glycosylated immunoglobulin (Ig) A antibodies. Although it
摘要 IgA肾病(IgA nephropathy,IgAN)是目前全球范围内最常见的原发性肾小球肾炎,20%～40%的患者在诊断后20年内进展为终末期肾病。IgAN的发病机制尚不明确,临床治疗主要以控制病情进展为主,缺乏特异性治疗方案。围绕半乳糖缺乏的IgA1(galactose-deficient IgA1,Gd-IgA1)开展的一系列研究提示IgAN发病涉及多个环节。该...
Conclusions Among patients with IgA nephropathy and proteinuria greater than 1 g/d, oral methylprednisolone was associated with an increased risk of serious adverse events, primarily infections. Although the results are consistent with potential benefit, definitive conclusions about treatment benefit cannot ...
ChemounyMathieu JablonskiMartin FlamantKidney InternationalPapista C, Lechner S, Ben Mkaddem S, et al. Gluten exac- erbates IgA nephropathy in humanized mice through glia- din-CD89 interaction. Kidney Int 2015; 88: 276-285.Papista C, Lechner S, Ben Mkaddem S, et al. Gluten exacerbates ...
Lechner SM, Papista C, Chemouny JM, Berthelot L, Monteiro RC (2016) Role of IgA receptors in the pathogenesis of IgA nephropathy. J Nephrol 29: 5-11.Lechner SM, Papista C, Chemouny JM, Berthelot L, Monteiro RC (2016) Role of IgA receptors in the pathogenesis of IgA nephrop- athy...
which share the same pathology features, in the light of peculiar clinical differences and progression tendencies, and hence need for selective treatments. The search for a personalized treatment in children with IgAV and in different ages of life should rely on the identification of different risks...