首创基因疗法早期研究积极,显著改善病症 2024年美国肾脏病学会(ASN)--肾脏周(Kidney Week)上,专注于开发肾脏疾病基因疗法的生物科技公司Purespring Therapeutics展示了其创新基因疗法PS-002治疗原发性免疫球蛋白肾病(IgA nephropathy,IgA肾病)的临床前研究结果。数据显示,该疗法能有效靶向肾脏足细胞,通过调节补体系...
参考文献: 1. IgA nephropathy in adults — treatment standard.NDT 2.IgA nephropathy: Treatment and prognosis.UTD 3The BAFF/APRIL system: emerging functions beyond B cell biology and autoimmunity. Cytokine Growth Factor Rev. 2013 Jun;24(3):203-15. 4.IgA nephropathy: Pathogenesis.UTD. 5.A Phas...
9. ERA Congress2022.Atrasentan for the Treatment of IgA Nephropathy: Interim Results from the AFFINITY Study. Presented May 20, 2022. 10. ERA Congress2022. Abstract FC 052. 11. Landmark Analysis Supports New Endpoints for...
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美国食品药品监督管理局（FDA）有条件批准布地奈德（budesonide）治疗原发性 IgA 肾病（IgA nephropathy）...
[31]MAIXNEROVA D, EL MEHDI D, RIZK D V, et al. New Treatment Strategies for IgA Nephropathy: Targeting Plasma Cells as the Main Source of Pathogenic Antibodies [J].Journal of clinical medicine, 2022, 11(10). [32]SELVASKANDAN H, GONZALEZ-MARTIN G, BARRATT J, et al. IgA nephropathy:...
New treatment for IgA nephropathy: enteric budesonide targeted to the ileocecal region ameliorates proteinuria. Nephrol Dial Transplant 2011; 26: 3237-3242Smerud HK, Barany P, Lindstrom K, et al. New treatment for IgA nephropathy: enteric budesonide targeted to the ileocecal region ame- lio...
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参考文献 [1]肾医通公众号. [2]Locatelli F, Del Vecchio L, Ponticelli C. Systemic and targeted steroids for the treatment of IgA nephropathy.Clin Kidney J. 2023;16(Suppl 2):ii40-ii46. Published 2023 Dec 4. doi:10.1093/ckj/sfa...
[21]Sung-Gyun Kim, Nam Vo, Sang-Ho Lee, Dwarakanathan Ranganathan, Lesley Inker, Mohamed El-Shahawy, Terri Spinelli, Khushboo Sheth, Todd Devries, Marianne Camargo, Andrew King, Alan Glicklich, Muh Wong, FC052: Atrasentan for the Treatment of IGA Nephropathy: Interim Results from the Affin...