SLC-T is a genetic marker in primary hypertension (HTN), HTN in pregnancy, diabetic nephropathy, and IgA nephropathy (IgA-N) with HTN. Patients with IgA-N have been reported to have enhanced SLC-T activity and are likely to have considerably lower renal fractional clearance of lithium. ...
WHITE-COAT HYPERTENSION, RELATIVE NOCTURNAL HYPERTENSION AND SUSTAINED HYPERTENSION ACCELERATES THE PROGRESSION OF IgA NEPHROPATHYThe progression of IgA-NP is influenced unfavourably by development and existence of hypertension. The treatment of hypertension (HTN) has an important role in these patients. ...
Evidence for genetic factors in the development and progression of IgA nephropathy. Background IgA nephropathy (IgAN) is the most common glomerulonephritis in the world among patients undergoing renal biopsy. Once considered a relatively benign condition, longitudinal follow-up studies have revealed that...
From the time of its first description,1,2 IgA nephropathy (IgAN) has been considered to be an immune complex disease, whose immunoglobulin moiety is now known to represent, in large part, mesangial and capillary wall deposits of an abnormal IgA1 with defects in its hinge region.3., 4.,...
BACKGROUND :Urinary micro-RNA (miRNA) level may serve as non-invasive disease markers for immunoglobulin A nephropathy (IgAN), but urinary miRNA targets identified in previous studies may represent kidney scarring rather than being specific for IgAN. We aim to identify urinary miRNA targets for ...
The findings of the present study indicate that periostracum cicadae induces apoptosis and improves kidney inflammation and fibrosis in IgA nephropathy rat models. Keywords: periostracum cicadae; IgA nephropathy; inflammation; fibrosis; apoptosis 1. Introduction Immunoglobulin A nephropathy (IgAN) is ...
Six IgA1 mAbs were cloned by this method; three potently neutralized type 3 Sabin and wt PV strains. The hybridoma mAbs were heterogeneous, expressed in monomeric, dimeric, and aberrant forms. We also used recombinant methods to convert two high-potency anti-PV IgG mAbs into dimeric IgA1 and...