Background: IgA nephropathy (IgAN) is a very common glo- merulonephritis worldwide. Nevertheless, treatment op- tions for primary IgAN are still largely based on opinion or weak evidence. There is a lack of large randomized con- trolled trials (RCT) that provide a definitive immunosuppres- ...
Globally, IgA nephropathy (IgAN) is the most common primary glomerulonephritis that can progress to renal failure. The exact pathogenesis of IgAN is not well defined, but current biochemical and genetic data implicate overproduction of aberrantly glycosylated IgA1. These aberrant immunoglobulins are chara...
Tissue-specific expression of renin-angiotensin system components in IgA nephropathy. Background: The renin-angiotensin II system (RAS) has been implicated in the development of glomerulonephritis. The aims of this study were to determine (1... C Miyake-Ogawa,M Miyazaki,K Abe,... - 《American...
BACKGROUND: Because humoral immunity is believed to play a pivotal role in the pathogenesis of IgA nephropathy (IgAN), a prospective placebo-controlled randomized study was started in patients with IgAN using mycophenolate mofetil (MMF). METHODS: A total of 34 patients with IgAN were treated with...
Childhood IgA nephropathyConfocal laser scanning microscopyGlomerular anionic chargeBackground: The proteinuria resulting from IgA nephropathy is secondary to altered charge-selective and/or size-selective properties of the glomerular capillary walls. However, the functional changes occurring within the ...
Background: IgA nephropathy (IgAN) is detected in Europe in 22% of glomerular diseases diagnosed by biopsy. The frequency of IgAN as cause of ESRD in Europe has increased in the last decades, accounting for 35% of young and adult transplanted patients. These data justify ...
IgA Nephropathy 来自 ResearchGate 喜欢 0 阅读量: 16 作者: Wardle, E. Nigel 摘要: A letter to the editor is presented in response to the article "IgA nephropathy," by J.V. Donadio and J.P. Grande in the September 5, 2002 issue. 关键词: Animals Mice Kidney Glomerulonephritis Immune ...
The Oxford classification of IgA nephropathy (IgAN) can evaluate each MEST-C score individually. We analysed a new grading system that utilised the total MEST-C score in predicting renal prognosis. Altogether, 871 IgAN patients were classified into three groups using the new Oxford classification sy...
The role of complement system in late stage of IgA nephropathy (IgAN) remains unknown. We therefore investigated the effects of complement system on worsening kidney function in advanced (stage 4 CKD) IgAN. Renal specimens of 69 IgAN patients who underwe
Background There is a clear need to refine the histological assessment in IgA Nephropathy (IgAN). We sought to investigate the clinical significance of the light microscopy (LM) pattern of glomerular injury and of the intensity of mesangial C3 staining in IgAN. Methods We conducted a retrospective...