Thus, Ig V gene mutation status and the percentages of (+) B-CLL cells appear to be accurate predictors of clinical outcome in B-CLL patients. These parameters, especially expression that can be analyzed conveniently in most clinical laboratories, should be valuable adjuncts to the present ...
We have isolated from a human genomic library a potentially functional and distinctive germline gene, designated IGLV6S1, that encodes for light chains of the VλVI subgroup. An identical germline gene was cloned from fibroblasts obtained from a patient with light-chain-associated amyloidosis (AL ...
We report the cDNA sequence of an expressed human V lambda II gene and present an RFLP analysis of the Ig gene family defined by this clone. This V lambda II gene was expressed in a monoclonal B cell line generated from a patient with SLE by transformation with EBV. The encoded lambda ...
Ig Heavy Chain Gene Rearrangements in T-Cell Acute Lymphoblastic Leukemia Exhibit Predominant Dh6-19 and Dh7-27 Gene Usage, Can Result in Complete V-D-J Rearrangements, and Are Rare in T-Cell Receptor αβ Lineage Author links open overlay panelTomasz Szczepański, Marja J. Pongers-Willem...
We generated surrogate light chain (SLC)-deficient mice carrying either a VκJκ–Cκ transgene under the control of the κ promoter and intron enhancer or a VκJκ gene segment targeted into its physiological position. Efficient rescue of B cell development was seen in the former and partial...
(SLC)-deficientbelieved to serve as a checkpoint that signals that amice carrying either a VkJk–Ck transgene under theproductive m chain has been expressed. Mice unablecontrol of the k promoter and intron enhancer or ato express either the membrane form of the IgH chainVkJkgene segment ...
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The Ig-la CBA and C3H mice responded with anti-α-1, 3 dextran, K Id-negative Ab. The BALB/c, congenic strain CB20 (BALB/c Ig-lb, carrying the C57BI/Ka, Ig-lb variable H (VH) gene complement and CH phenotype, made anti-α-1, 3 dextran K Id-negative Ab of the Ig-lb ...
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The generation of this repertoire depends on the somatic recombination of the variable (V), diversity (D), and joining (J) genes in the Ig loci of developing B cells. It has been known for some time that individual V, D, and J gene segments rearrange at different frequencies, but the ...