We have investigated the mechanism of the inhibition of IFN-gamma induction of the murine A alpha class II MHC gene by cAMP and E series prostaglandins (PGEs). 151 base pairs of the A alpha promoter were sufficient to confer positive regulation by IFN-gamma and negative regulation by cAMP ...
IFN gamma function includes the following: antiviral activity, tumor antiproliferative activity, induction of class I and II MHC, macrophage activation, and enhanced immunoglobulin secretion by B lymphocytes. IFN gamma is involved in cytokine regulation and also acts synergistically with other cytokines...
Recently we demonstrated that prolonged administration of IFN-gamma prevented the development of GVHD in a MHC-mismatched murine BMT model. Treatment with IFN-gamma allowed the development of mature donor-derived allo-tolerant immunocompetent cells in complete chimeric recipients. Here we present data ...
在多种类型的细胞中,γ干扰素可诱导细胞因子的产生和上调不同的膜蛋白的表达,包括I/II型主要组织相容性复合体(MHC-I,MHC-II)、Fc受体、白细胞粘附分子、B7家族抗原。γ干扰素能有效活化巨噬细胞、指导B细胞免疫球蛋白的合成、类型转化和分泌。γ干扰素也能通过抑制Th2的分化和刺激Th1的生长而影响...
IFN-gamma 通过促进组织蛋白酶B/CTSB、H/CTSH 和L/CTSL 等几个关键分子的表达,上调细胞表面的MHC II 复合物。IFN-gamma 通过影响造血干细胞的发育、静止和分化,参与造血干细胞在发育和稳态条件下的调控。 蛋白编号:P01579 (Q24-G161) 基因ID:3458 品牌介绍:• MCE (MedChemExpress) 拥有200 多种全球...
干扰素-γ是一种有效的多功能细胞因子,主要由活化的NK细胞和T细胞释放。IFN-γ的主要特征在于其抗病毒活性,然后被证明具有多种功能,例如抗增殖、免疫调节和促炎活性。IFN-γ可通过抗原呈递细胞上调MHC I类和II类抗原的表达。 序列 MHGTVIESLESLNNYFNSSGIDVEEKSLFLDIWRNWQKDGDMKILQSQIISFYLRLFEVLKDNQAISNNISVIESHLIT...
IFN-gamma is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-gamma receptors are present in most immune cells,which respond to IFN-gamma signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of...
IFNγ功能包括:抗病毒活性,肿瘤抗增殖活性,I类和II类MHC的诱导,巨噬细胞活化以及B淋巴细胞增强的免疫球蛋白分泌。 IFNγ参与细胞因子的调节,并与其他细胞因子协同作用。 IFNγ的激活是通过IFNγ受体I和II的结合并激活JAK-STAT途径进行的。 IFNγ与IFNα或IFNβ没有任何同源性,但是人IFNγ与小鼠IFNγ具有约40%的...
IFN gamma function includes the following: antiviral activity, tumor antiproliferative activity, induction of class I and II MHC, macrophage activation, and enhanced immunoglobulin secretion by B lymphocytes. IFN gamma is involved in cytokine regulation and also acts synergistically with other cytokines. ...
干扰素γ在激活对病毒和肿瘤的先天性和适应性免疫反应方面具有更广泛的作用,部分是通过上调参与细胞周期调节、凋亡和抗原加工/呈递的基因的转录。尽管如此,啮齿动物和人类滋养层细胞对IFNG的反应减弱,这反映了这些细胞对IFNG介导的主要组织相容性复合体(MHC)II类移植抗原表达的激活的抵抗力。