We propose IFNg-induced programmed cell death 1 ligand 1 (PD-L1) expression as a novel mechanism by which IFNg impairs tumor immunity. When tumor cells encounter CTLs in the local environment, they detect them via the high concentration of IFNg secreted from CTLs, which induces PD-L1 ...
程序性细胞死亡1 (PD-1, CD279)受体蛋白,3D呈现 程序性细胞死亡1 (PD-1, CD279)受体蛋白,3D呈现 CD4表面蛋白。3 d演示。 人血清白蛋白,3D渲染。漫画&线框 人血清白蛋白,三维渲染。卡通雕塑作品 地西泮与人血清白蛋白结合的药物分子,3D 人血清白蛋白,三维渲染。卡通和线框 人血清白蛋白,3D渲染...
11505 Background: Anti-PD-1(L1) therapies appear to be less efficacious in NSCLC patients whose tumors have EGFR activating mutations, but the underlying mechanism is poorly understood. We investigated the relationship between Methods: Flow cytometry and/or quantitative PCR were used to evaluate gene...
However, when treated with IFNg, analyses of HLA-DR, HLA class I and PD-L1 surface expression on Ma-Mel-36 cells (hereafter referred to as Ma-Mel-36_bulk cells) demonstrated that the cell line consisted in equal parts of IFNg-sensitive and IFNg-resistant subpopulations (Fig. 1b). Both...
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Veterinary MicrobiologyPD-1 blockade inhibits lymphocyte apoptosis and restores proliferation and anti-viral immune functions of lymphocyte after CP and NCP BVDV infection in vitroDoi: 10.1016/j.vetmic.2018.10.014 Cellular ImmunologyNK Cells Suppress CD8+ T Cell Immunity via NKG2D in Severe Aplastic ...
Researchers have devoted substantial efforts to elucidate the biological properties of exosomes and their components and their roles in central nervous system disease, such as AD, Parkinson's disease (PD) and Huntington's disease (HD) [38]. At the same time, several exosome databases have been ...
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