IFN-γ主要由Th1型细胞产生,属于II型细胞因子中干扰素家族中的一员,是一类分泌型糖蛋白,由143个氨基酸组成,相对分子质量是16942。IFN-γ主要由活化的T细胞和NK细胞产生,具有调节机体免疫状态,介导细胞免疫,加强受体介导的吞噬功能,增强巨噬细胞和中性粒细胞的杀伤活性,具有抗病毒感染及抗肿瘤等生物学活性。
IFNG is produced predominantly by natural killer (NK) and natural killer T (NKT) cells as part of the innate immune response, and by CD4 (MIM 186940) and CD8 (see MIM 186910) cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops (Schoenborn and Wilson, ...
IFNG is produced predominantly by natural killer (NK) and natural killer T (NKT) cells as part of the innate immune response, and by CD4 (MIM 186940) and CD8 (see MIM 186910) cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops (Schoenborn and Wilson, ...
+和CD8+T细胞中分泌IFN-γ、IL-2和TNF-α的细胞百分比与对照组相比均显著降低(P<0.05);而EB病毒抗原肽刺激后,2型糖尿病患者外周血分泌IFN-γ、IL-2和TNF-α的CD8+T细胞百分比则显著高于对照组(P<0.05),且分泌TNF-α的细胞比例与HbA1C呈显著正相关(P<0.05).结论 2型糖尿病患者CD4+和CD8+T细胞分泌能力...