Human Anti-IFN-gamma Neutralizing Antibodies as Selective IFN-gamma Pathway InhibitorsThis invention provides antibodies that interact with or bind to human interferon-gamma (IFN-γ) and methods for treating IFN-γ mediated diseases by administering a pharmaceutically effective amount of antibodies to ...
Activation of IFN gamma takes place through binding of IFN gamma receptor I and II, and activating the JAK-STAT pathway. IFN gamma does not show any homology with IFN alpha or IFN beta but human IFN gamma shows about 40% sequence homology with mouse IFN gamma. IFN gamma is upreg...
Activation of IFN gamma takes place through binding of IFN gamma receptor I and II, and activating the JAK-STAT pathway. IFN gamma does not show any homology with IFN alpha or IFN beta but human IFN gamma shows about 40% sequence homology with mouse IFN gamma. IFN gamma is upregulated ...
. IFN-γ binds to a receptor complex and initiates signal transduction via the JAK/STAT pathway; this culminates in the transcription and activation of many genes that control a diverse array of immunological functions (de Weerd & Nguyen; Krause et al.). IFN-γ stimulates the antimicrobi...
Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy Loss of IFN-gamma pathway genes in tumor cells as a mechanism of resistance to anti-CTLA-4 therapy. Cell 2016;167:397-404... J Gao,L Shi,H Zhao,... - 《Cell》 被引量: 169发表: 20...
IFN-gamma 产品 信息 英文名称 : Interferon gamma 中文名称 :干扰素 -γ 靶点别称 : IFNG , IFN-Gamma , Interferon-γ 物种: Human / Mouse 属性: Protein / Antibody / Kits 标记: Biotin-labeled / Unconjugate
Binding to the receptor activates the JAK/STAT pathway which in turn activates IFN γ responsive genes. While IFN γ can inhibit viral replication, it also works as an immune-modulator and immune-stimulator by increasing surface expression of class I MHC proteins (PMID: 19268625; 10688427) 实验...
JAK/STAT Pathway MDSC-induced Immune Suppression Myeloid-Derived Suppressor Cells Regulatory T Cells Shedding MICA/B Antigens Stat3-mediated Tumor Escape T Follicular Helper Cell Pathway TH1 Pathway (Cellular Immune Response) Th17 Biology TH2 Pathway (Humoral Immune Response) ...
As a result, HEK-Dual™ IFN-γ cells allow studying the activation of JAK/STAT-1 pathway, by monitoring the activity of two different reporters, SEAP or Lucia luciferase. Both reporter proteins are readily measurable in the cell culture supernatant when using QUANTI-Blue™ Solution, a ...
TH2 Pathway (Humoral Immune Response) Pages Quality Control ELISA Kits and Sets Related FAQs There are no FAQs for this product. Certificate of Analysis Lot #: Customers Also Purchased ELISA MAX™ Standard Set Human IL-2 ELISA MAX™ Standard Set Human TNF-α ELISA MAX™ St...