IFN-beta 3 differentially regulates the function of T cell subsets in MS and EAEMultiple sclerosisInterferon betaT cell subsetsInflammationExperimental AutoimmuneEncephalomyelitisMultiple sclerosis (MS) is considered as a T cell mediated autoimmune disease of the CNS, although a pathogenic role has also ...
Function Interferon is a protein that acts as a battling sergeant, marshaling an army of eager soldiers, and issuing commands for an oncoming war. It is essentially the “wake up, trouble is coming” protein, helping to launch immune defenses against pathogens. ...
for the decreased or lack of ability to induce FoxA1 þ Tregs, and that IFNb signalling is central for activation of neuronal FoxA1 and its target gene Pdl1, which in turn are indispensable for the function of neurons to interact and convert pathogenic T cells to FoxA1 þ Treg cells....
IFNB1: Has antiviral, antibacterial and anticancer activities. Belongs to the alpha/beta interferon family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 9p21. Cellular Component: extracellular space; extracellular region. Molecular Function: interferon-alpha/bet...
Warning: Invalid argument supplied for foreach() in /home/prospec/public_html/cart/Smarty-2.5.0/plugins/function.interpro.php on line 30 Gene: Name:IFNB1Synonyms:IFB, IFNB Protein synonyms/aliases: Interferon beta precursor (IFN-beta) (Fibroblast interferon). Protein Family: Belongs to ...
Long latency event-related auditory evoked potentials, particularly the P300 wave, constitute an objective electrophysiological index of cognitive function... HS Panitch - 《Neurology》 被引量: 663发表: 1987年 The effect of interferon-β on blood—brain barrier disruptions demonstrated by constrast-enh...
Our results show that TGF-β1 and IFN-γ cross-regulate Ag presentation by influencing the transcription of several genes associated with antigen presentation function, which may represent an important mechanism limiting T cell activation during an immune response.doi:10.1189/jlb.72.1.163...
These findings provide the first evidence for a function of STAT3 and STAT5A/B in the IFN-alphabeta response, and support a model in which the IFN-alphabeta receptor initiates both pro- and antiapoptotic responses through STAT1, and STAT3 and STAT5A/B, respectively. 展开 ...
IFN-beta is anticipated to have an important function in mucosal tolerance, as it is one of the major cytokines produced by plasmacytoid dendritic cells, and has recently been suggested as central to the maintenance of mucosal homeostasis. Here, we have investigated whether oral tolerance is ...
The importance of TBK1 in innate immunity has been demonstrated in mammalian, however the characterization and function of TBK1 in avian remains largely unknown. In this study, we cloned duck TBK1 (duTBK1) from duck embryo fibroblasts (DEFs) for the first time, which encoded 729 amino acids ...