IFNγ可上调多种细胞表达PDL1，阻止Th1细胞分化，损害效应肿瘤免疫。IFNγ还通过减少Bcl-2的表达，上调F...
PD-1: Programmed Cell Death Protein-1 PD-L1: Programmed Cell Death Ligand 1 ICIs: Immune Checkpoint Inhibitors HPD: Hyperprogressive Disease IFN-γ: Interferon-gamma IFN-α: Interferon-alpha IFN-β: Interferon-beta FBS: Fetal Bovine Serum FFPE: Formalin-fixed paraffin-embedded H&E...
In the TME, programmed death-ligand 1 (PD-L1) expression on cancer cells is mainly regulated by Interferon-gamma (IFN-γ), which induces T cell exhaustion and enables tumor immune evasion. In this study, we demonstrate that acidosis, a common char‑ acteristic of solid...
Homeostasis encompasses not only immunosuppressive, tolerogenic molecules CD200, IDO, PDL1, and SOCS2, but also those that are immunostimulatory (CD40). CD40 regulates DC activation, cytokine production, and non-canonical NF-κB signaling (Ma and Clark, 2009). Hence, further work is needed to ...
Ido1/ (nullizygous) mice exhibited impaired pulmonary metastases neovascularization and outgrowth that was driven by IFN纬 (interferon gamma) in the absence of IDO1-dependent IL6 production. Hypoxia was likewise elevated, and these stress conditions increased the susceptibility of the metastatic tumor...
To investigate the effect of PD-L1 on host immunity, we compared the tumour-infiltrating immune cells in peritoneal disseminated tumour of HM1-pdl1 (PD-L1-overexpressing HM-1) and in that of HM1-Mirpdl1. As shown in Supplementary Figure S4A, the number of CD8-positive tumour-infiltrating ...
The PE anti-mouse IFN-gamma Antibody from BioLegend is a Rat Monoclonal antibody to IFNG. This antibody recognizes Mouse antigen. The PE anti-mouse IFN-gamma Antibody has been validated for the following applications: Staining, and Flow Cytometry. PE anti-mouse IFN-gamma [XMG1.2] Product...
Hypergammaglobulinemia = 1 point 0 0 0 0 0 Anti-ssDNA/ anti-dsDNA antibodies = 1 point 0 0 0 0 0 Antinuclear antibodies = 1 point 0 0 0 0 0 Anti Ro/SSA; anti La/ SSB antibodies = 1 point 0 0 0 0 0 Typical lupus histology = 1 point 0 0 0 0 0 Immune complex or compleme...
PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction. EbioMedicine 2018, 36, 367–375. [Google Scholar] [CrossRef] Garcia-diaz, A.; Sanghoon, D.; Moreno, B.H.; Saco, J.; Escuin-Ordinas, H.; Rodriguez, ...
Homeostasis encompasses not only immunosuppressive, tolerogenic molecules CD200, IDO, PDL1, and SOCS2, but also those that are immunostimulatory (CD40). CD40 regulates DC activation, cytokine production, and non-canonical NF-κB signaling (Ma and Clark, 2009). Hence, further work is needed to ...